Distinct pharmacology of rat and human histamine H3 receptors: role of two amino acids in the third transmembrane domain
X Ligneau, S Morisset… - British journal of …, 2000 - Wiley Online Library
Starting from the sequence of the human histamine H3 receptor (hH3R) cDNA, we have
cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall …
cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall …
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation
C Liu, SJ Wilson, C Kuei, TW Lovenberg - Journal of Pharmacology and …, 2001 - ASPET
The recently identified histamine H 4 receptor has revealed a potential new complexity for
the role of histamine in the immune system. To begin to understand the role of this receptor …
the role of histamine in the immune system. To begin to understand the role of this receptor …
Compared pharmacology of human histamine H3 and H4 receptors: structure–activity relationships of histamine derivatives
F Gbahou, L Vincent… - British journal of …, 2006 - Wiley Online Library
Various histamine derivatives were investigated at the human H3 receptor (H3R) and H4
receptor (H4R) stably expressed in human embryonic kidney (HEK)‐293 cells using [125I] …
receptor (H4R) stably expressed in human embryonic kidney (HEK)‐293 cells using [125I] …
Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants
D Wifling, K Löffel, U Nordemann… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Some histamine H 4 receptor ligands act as inverse agonists at
the human H4 receptor (hH4R), a receptor with exceptionally high constitutive activity, but as …
the human H4 receptor (hH4R), a receptor with exceptionally high constitutive activity, but as …
Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms
A Rouleau, A Heron, V Cochois, C Pillot… - Journal of …, 2004 - Wiley Online Library
The existence of mouse H3‐receptor isoforms was investigated by PCR analysis and cDNA
cloning. Splicing mechanisms previously reported in various species are conserved in the …
cloning. Splicing mechanisms previously reported in various species are conserved in the …
An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive …
G Bongers, KM Krueger, TR Miller… - … of Pharmacology and …, 2007 - ASPET
In this article, we pharmacologically characterized two naturally occurring human histamine
H3 receptor (hH3R) isoforms, hH3R (445) and hH3R (365). These abundantly expressed …
H3 receptor (hH3R) isoforms, hH3R (445) and hH3R (365). These abundantly expressed …
Cloning of rat histamine H3 receptor reveals distinct species pharmacological profiles
TW Lovenberg, J Pyati, H Chang, SJ Wilson… - … of Pharmacology and …, 2000 - ASPET
The recent cloning and characterization of the human histamine H3 receptor cDNA marked
a significant step toward a greater understanding of the role of this receptor in the central …
a significant step toward a greater understanding of the role of this receptor in the central …
Pharmacological differences between human and guinea pig histamine H1 receptors: Asn84 (2.61) as key residue within an additional binding pocket in the H1 …
M Bruysters, A Jongejan, M Gillard… - Molecular …, 2005 - ASPET
We tested several histamine H1 receptor (H1R) and antagonists for their differences in
agonists binding affinities between human and guinea pig H1Rs transiently expressed in …
agonists binding affinities between human and guinea pig H1Rs transiently expressed in …
Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and …
HD Lim, A Jongejan, RA Bakker, E Haaksma… - … of Pharmacology and …, 2008 - ASPET
Using the natural variation in histamine H4 receptor protein sequence, we tried to identify
amino acids involved in the binding of H4 receptor agonists. To this end, we constructed a …
amino acids involved in the binding of H4 receptor agonists. To this end, we constructed a …
Cloning and pharmacological characterization of the monkey histamine H3 receptor
Species differences have been described previously for histamine H3 receptor
pharmacology. Rat selective histamine H3 receptor ligands such as ciproxifan and A …
pharmacology. Rat selective histamine H3 receptor ligands such as ciproxifan and A …