Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe

WX Wang, WL Jiang, H Guo, Y Li, CY Li - Chemical Communications, 2021 - pubs.rsc.org
A novel water-soluble near-infrared fluorescent probe named QX-P with simple synthesis is
developed. QX-P has high sensitivity and selectivity to ALP. Moreover, the probe can not …

Ratiometric detection and bioimaging of endogenous alkaline phosphatase by a NIR fluorescence probe

YA Feng, H Xu, Y Zhou, BJ Wang, J Xiao… - Sensors and Actuators B …, 2022 - Elsevier
A novel near-infrared (NIR) fluorescent probe (SWJT-3) was designed based on phosphate
protection of the electron donating group of the hemicyanine for the ratiometric …

In vivo imaging of alkaline phosphatase in tumor-bearing mouse model by a promising near-infrared fluorescent probe

HW Liu, XX Hu, L Zhu, K Li, Q Rong, L Yuan, XB Zhang… - Talanta, 2017 - Elsevier
Alkaline phosphatase (ALP), one of the important hydrolases, is associated with the
progress of many diseases as a well-defined biomarker. Fluorescence imaging of ALP in …

Facile and sensitive near-infrared fluorescence probe for the detection of endogenous alkaline phosphatase activity in vivo

SJ Li, CY Li, YF Li, J Fei, P Wu, B Yang… - Analytical …, 2017 - ACS Publications
Alkaline phosphatase (ALP) is an essential enzyme and widely distributes in a variety of
tissues. To date, various nanomaterial and small-molecule fluorescent probes for ALP have …

A novel near-infrared fluorescent probe for detecting intracellular alkaline phosphatase and imaging of living cells

L Xu, X He, Y Huang, P Ma, Y Jiang, X Liu… - Journal of materials …, 2019 - pubs.rsc.org
Development of novel near-infrared (NIR) fluorescent probes for the monitoring of active
substances in living organism is desirable in biological studies. Herein, we designed a novel …

A unique off-on near-infrared cyanine-based probe for imaging of endogenous alkaline phosphatase activity in cells and in vivo

Z Gao, J Sun, M Gao, F Yu, L Chen, Q Chen - Sensors and Actuators B …, 2018 - Elsevier
Alkaline phosphatase (ALP) is a class of enzymes that are widely found in various tissues of
the human body. It plays important roles in regulating diverse cellular functions. The …

Near-infrared ratiometric probe with a self-immolative spacer for rapid and sensitive detection of alkaline phosphatase activity and imaging in vivo

X Zhang, X Chen, K Liu, Y Zhang, G Gao, X Huang… - Analytica Chimica …, 2020 - Elsevier
Alkaline phosphatase (ALP), an enzyme that catalyzes the hydrolysis of phosphate groups,
is closely associated with many diseases, including bone disease, prostate cancer, and …

Reaction-based off–on near-infrared fluorescent probe for imaging alkaline phosphatase activity in living cells and mice

Y Tan, L Zhang, KH Man, R Peltier… - … Applied Materials & …, 2017 - ACS Publications
Alkaline phosphatases are a group of enzymes that play important roles in regulating
diverse cellular functions and disease pathogenesis. Hence, developing fluorescent probes …

Red–near-infrared fluorescent probe for time-resolved in vivo alkaline phosphatase detection with the assistance of a photoresponsive nanocontainer

X Jie, M Wu, H Yang, W Wei - Analytical chemistry, 2019 - ACS Publications
The monitoring of alkaline phosphatase (ALP) activity in different tissues is significant for
disease diagnosis and therapy. However, the time-resolved in vivo sensing of ALP activity …

Near-infrared mito-specific fluorescent probe for ratiometric detection and imaging of alkaline phosphatase activity with high sensitivity

Q Zhang, S Li, C Fu, Y Xiao, P Zhang… - Journal of Materials …, 2019 - pubs.rsc.org
Fluorescent probe-based analytical methods for biological species have gained increasing
attention for their powerful detection and imaging capabilities. However, it is still …