In-frame mutations in nuclear lamin A/C lead to a multitude of tissue-specific degenerative
diseases known as the 'laminopathies'. Previous studies have demonstrated that lamin A/C …

Lamins are components of the peripheral nuclear lamina and interact with heterochromatic
genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being …

Nuclear lamins play important roles in the organization and structure of the nucleus;
however, the specific mechanisms linking lamin structure to nuclear functions are poorly …

Although activated caspase 6 is capable of cleaving both A-and B-type lamins during
apoptosis, the higher-order structure of the nuclear lamina may cause a differential …

The distinct spatial architecture of the apical actin cables (or actin cap) facilitates rapid
biophysical signaling between extracellular mechanical stimuli and intracellular responses …

Nuclear lamins were originally described as the main constituents of the nuclear lamina, a
filamentous meshwork closely associated with the inner nuclear membrane. However, within …

Nuclear pores are sophisticated gateways on the nuclear envelope that control
macromolecular transport between the cytoplasm and nucleoplasm. So far the structural and …

The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …

Although abnormal nuclear structure is an important criterion for cancer diagnostics,
remarkably little is known about its relationship to tumor development. Here we report that …

Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …