Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in
laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization …

The lamins are nuclear intermediate filament-type proteins forming the nuclear lamina
meshwork at the inner nuclear membrane as well as complexes in the nucleoplasm. The …

The nuclear lamina is essential for the proper structure and organization of the nucleus.
Deregulation of A‐type lamins can compromise genomic stability, alter chromatin …

Chromatin is organized in a highly ordered yet dynamic manner in the cell nucleus, but the
principles governing this organization remain unclear. Similarly, it is unknown whether, and …

Lamins, which form the nuclear lamina, not only constitute an important determinant of
nuclear architecture, but additionally play essential roles in many nuclear functions …

Lamins constitute an integral structural component of the nuclear lamina. However, their
impact on the structure and stability of chromosome territories, and on the regulation of gene …

Mutations in LMNA, which encodes A-type lamins, result in disparate diseases, known
collectively as laminopathies, that affect distinct tissues, including striated muscle and …

Lamin A/C is part of the nuclear lamina, a meshwork of intermediate filaments underlying the
inner nuclear membrane. The lamin network is anchoring a complex set of structural and …

The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining
the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses …

Lamins are the main component of the nuclear lamina, a protein meshwork at the inner
nuclear membrane which primarily provide mechanical stability to the nucleus. Lamins, type …