The Clostridium botulinum C2 Toxin Subunit C2IIa Delivers Enzymes with Positively Charged N-Termini into the Cytosol of Target Cells
S Heber, J Borho, N Stadler, F Wondany, I König… - Toxins, 2023 - mdpi.com
The binary Clostridium (C.) botulinum C2 toxin consists of two non-linked proteins. The
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …
Formation of a Biologically Active Toxin Complex of the Binary Clostridium botulinum C2 Toxin without Cell Membrane Interaction
E Kaiser, G Haug, M Hliscs, K Aktories, H Barth - Biochemistry, 2006 - ACS Publications
Clostridium botulinum produces a binary toxin, which is composed of two separate proteins.
The enzyme component, C2I, is an ADP-ribosyltransferase which modifies G-actin of …
The enzyme component, C2I, is an ADP-ribosyltransferase which modifies G-actin of …
Role of Host Cell Chaperones in Cellular Uptake of Clostridium Botulinum C2 Toxin
E Kaiser, H Barth - The Open Toxinology Journal, 2010 - benthamopen.com
The binary C2 toxin from Clostridium botulinum consists of two separate proteins: the
transport component C2IIa delivers the enzyme component C2I into the cytosol of eukaryotic …
transport component C2IIa delivers the enzyme component C2I into the cytosol of eukaryotic …
Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells
D Blöcker, K Pohlmann, G Haug, C Bachmeyer… - Journal of Biological …, 2003 - ASBMB
The binary Clostridium botulinum C2 toxin consists of two individual proteins, the transport
component C2II (80 kDa) and the enzyme component C2I, which ADP-ribosylates G-actin in …
component C2II (80 kDa) and the enzyme component C2I, which ADP-ribosylates G-actin in …
The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes
J Eisele, S Schreiner, J Borho, S Fischer… - Frontiers in …, 2022 - frontiersin.org
The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …
Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification
H Barth, D Blöcker, J Behlke… - Journal of Biological …, 2000 - ASBMB
The actin-ADP-ribosylating binaryClostridium botulinum C2 toxin consists of two individual
proteins, the binding/translocation component C2II and the enzyme component C2I. To elicit …
proteins, the binding/translocation component C2II and the enzyme component C2I. To elicit …
Genetically engineered clostridial C2 toxin as a novel delivery system for living mammalian cells
J Fahrer, R Plunien, U Binder, T Langer… - Bioconjugate …, 2010 - ACS Publications
The C2 toxin of Clostridium botulinum is a binary bacterial protein toxin, comprising the
enzyme component C2I and the separate binding/translocation component C2IIa. C2IIa …
enzyme component C2I and the separate binding/translocation component C2IIa. C2IIa …
The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components
H Barth, R Roebling, M Fritz, K Aktories - Journal of Biological Chemistry, 2002 - ASBMB
The binary Clostridium botulinum C2 toxin is composed of the enzyme component C2I and
the binding component C2II, which are individual and non-linked proteins. Activated C2IIa …
the binding component C2II, which are individual and non-linked proteins. Activated C2IIa …
Intracellular trafficking of Clostridium botulinum C2 toxin
M Nagahama, C Takahashi, K Aoyanagi, R Tashiro… - Toxicon, 2014 - Elsevier
Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic component (C2I)
and binding component (C2II). The activated binding component (C2IIa) forms heptamers …
and binding component (C2II). The activated binding component (C2IIa) forms heptamers …
Channel Formation by the Binding Component of Clostridium botulinum C2 Toxin: Glutamate 307 of C2II Affects Channel Properties in Vitro and pH-Dependent C2I …
D Blöcker, C Bachmeyer, R Benz, K Aktories… - Biochemistry, 2003 - ACS Publications
The binding component (C2II) of the binary Clostridium botulinum C2 toxin mediates
transport of the actin ADP-ribosylating enzyme component (C2I) into the cytosol of target …
transport of the actin ADP-ribosylating enzyme component (C2I) into the cytosol of target …