Anti-tumor effects and cellular mechanisms of resveratrol

G Han, J Xia, J Gao, Y Inagaki, W Tang… - Drug discoveries & …, 2015 - jstage.jst.go.jp
Summary Resveratrol (3, 5, 4'-trihydroxystilbene) is a phytoalexin contained in a variety of
plants, such as grapes, berries and especially in the dried roots of Polygonum cuspidatum …

[HTML][HTML] In vino veritas: a tale of two sirt1s?

SH Koo, M Montminy - Cell, 2006 - cell.com
Resveratrol increases life span in lower organisms by activating the NAD+-dependent
histone deacetylase Sirt1. Studies by Lagouge et al.(2006) and Baur et al.(2006) now show …

Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action

MC Scherzberg, A Kiehl, A Zivkovic, H Stark… - Toxicology and Applied …, 2015 - Elsevier
Abstract (Z)-3, 5, 4′-Trimethoxystilbene (Z-TMS) is a resveratrol analog with increased
antiproliferative activity towards a number of cancer cell lines compared to resveratrol, which …

Resveratrol induces cell cycle arrest and apoptosis in malignant NK cells via JAK2/STAT3 pathway inhibition

L Quoc Trung, JL Espinoza, A Takami, S Nakao - PloS one, 2013 - journals.plos.org
Natural killer (NK) cell malignancies, particularly aggressive NK cell leukaemias and
lymphomas, have poor prognoses. Although recent regimens with L-asparaginase …

Growth‐stimulatory effect of resveratrol in human cancer cells

M Fukui, N Yamabe, KS Kang… - Molecular …, 2010 - Wiley Online Library
Earlier studies have shown that resveratrol could induce death in several human cancer cell
lines in culture. Here we report our observation that resveratrol can also promote the growth …

Regulation of cell survival by resveratrol involves inhibition of NFκB‐regulated gene expression in prostate cancer cells

DA Benitez, MA Hermoso, E Pozo‐Guisado… - The …, 2009 - Wiley Online Library
BACKGROUND Polyphenols have been proposed as antitumoral agents. We have shown
that resveratrol (RES) induced cell cycle arrest and promoted apoptosis in prostate cancer …

Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

L Peng, D Jiang - PLoS One, 2018 - journals.plos.org
Resveratrol shows potent anti-tumor therapeutic properties in various tumors. However, the
exact effect of resveratrol on osteosarcoma cells, especially cancer stem cells, remains …

Resveratrol-like compounds as SIRT1 activators

L Ciccone, E Piragine, S Brogi, C Camodeca… - International Journal of …, 2022 - mdpi.com
The sirtuin 1 (SIRT1) activator resveratrol has emerged as a promising candidate for the
prevention of vascular oxidative stress, which is a trigger for endothelial dysfunction …

Resveratrol: Biological and pharmaceutical properties as anticancer molecule

T Hsieh, JM Wu - Biofactors, 2010 - Wiley Online Library
There is ample evidence that shows an inverse relationship between consumption of
fruit/vegetable‐rich diets and the risk of cancer at various anatomical sites. In this review, we …

Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer

TY Alhazzazi, P Kamarajan, N Joo, JY Huang… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Several sirtuin family members (SIRT1‐7), which are evolutionarily
conserved NAD‐dependent deacetylases, play an important role in carcinogenesis …