Drugs in lactation

RHJ Verstegen, S Ito - Journal of Obstetrics and Gynaecology …, 2019 - Wiley Online Library
Although most medications can be taken safely during breastfeeding, potential risks of infant
toxicity do exist because all medications will be excreted into the breast milk to some extent …

Clinical lactation studies and the role of pharmacokinetic modeling and simulation in predicting drug exposures in breastfed infants

PO Anderson, JD Momper - Journal of Pharmacokinetics and …, 2020 - Springer
The relative lack of information on medication use during breastfeeding is an ongoing
problem for health professionals and mothers alike. Most nursing mothers are prescribed …

Safety of medicines during breastfeeding–from case report to modeling: a contribution from the ConcePTION project

E Cardoso, M Guidi, N Nauwelaerts… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Despite many research efforts, current data on the safety of medicines during
breastfeeding are either fragmented or lacking, resulting in restrictive labeling of most …

Non-clinical models to determine drug passage into human breast milk

D Ventrella, M Forni, ML Bacci… - Current Pharmaceutical …, 2019 - ingentaconnect.com
Background: Successful practice of clinical perinatal pharmacology requires a thorough
understanding of the pronounced physiological changes during lactation and how these …

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the …

N Nauwelaerts, J Macente, N Deferm, RH Bonan… - Pharmaceutics, 2023 - mdpi.com
Women commonly take medication during lactation. Currently, there is little information
about the exposure-related safety of maternal medicines for breastfed infants. The aim was …

Using pharmacokinetics to predict the effects of pregnancy and maternal–infant transfer of drugs during lactation

GD Anderson - Expert opinion on drug metabolism & toxicology, 2006 - Taylor & Francis
Knowledge of pharmacokinetics and the use of a mechanistic-based approach can improve
our ability to predict the effects of pregnancy for medications when data are limited. Despite …

Modeling drug passage into human milk

PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
Breastfeeding has positive health consequences for both the breastfed infant and the
nursing mother. 1, 2 Although information on drug use during lactation is available through …

Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically‐based pharmacokinetic model

K Abduljalil, A Pansari, J Ning… - CPT: pharmacometrics & …, 2021 - Wiley Online Library
There is a risk of exposure to drugs in neonates during the lactation period due to maternal
drug intake. The ability to predict drugs of potential hazards to the neonates would be useful …

Neonatal exposure to drugs in breast milk

PJ McNamara, M Abbassi - Pharmaceutical research, 2004 - Springer
There are many benefits of breast-feeding both for the infant and for the mother. Nursing
mothers who are also taking medications or exposed to environmental hazards may be …

Studying drugs in human milk: time to unify the approach

EJ Begg, SB Duffull, LP Hackett… - Journal of Human …, 2002 - journals.sagepub.com
The trend globally for mothers to breastfeed has highlighted the need for information on drug
transfer into breast milk and the extent to which the suckling neonate may be exposed and …