Pregnancy is associated with several physiological changes that can alter the
pharmacokinetics (PK) and pharmacodynamics of drugs. These may require dosing …

The two ultimate goals of using maternal medications during breastfeeding are (i) to provide
definitive therapy for maternal conditions for which the drugs have been prescribed, and (ii) …

The topic of drug ingestion related to pregnancy, and the peri-pregnant period including
lactation has always been important but under-studied. It is therefore gratifying to see that in …

Pregnancy, childbirth and lactation pose unique challenges in terms of drug therapy. The
pregnant mother and her unborn child are exceptionally vulnerable from a physiological …

The advantages of human milk are well known and surpass the simple nutrition facts. Not
only does it protect infants against infections such as gastroenteritis, otitis media, and upper …

The fetus is exposed to many xenobiotic agents during pregnancy through placental drug
transfer; the infant is exposed through breastfeeding. The effects of the drugs on the fetus or …

This book consists of the following 10 chapters: Breast-feeding today; Milk production and
the effects of drugs; Determinants of drug excretion in breast milk; Determinants of drug …

In spite of significant exposure to drugs and chemicals through breast milk, there are very
few reports of documented adverse effects on the infant. It is perhaps appropriate to consider …

Two goals when counseling breastfeeding mothers taking medication are protecting the
infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a …

Pregnant women and their fetuses are orphan populations with respect to the safety and
efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion …