Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?

P Bhattacharya, R Kanagasooriyan… - Current Opinion in …, 2022 - Elsevier
Atherosclerosis is a lipid-driven disease of the artery characterized by chronic non-resolving
inflammation. Despite availability of excellent lipid-lowering therapies, atherosclerosis …

Atherosclerosis—Underlying inflammatory mechanisms and clinical implications

S Patel, DS Celermajer, S Bao - The international journal of biochemistry & …, 2008 - Elsevier
Inflammation plays an important role in the initiation and progression of atherosclerosis but
many of its underlying mechanisms remain to be explored. Atherosclerotic plaques which …

Anti-inflammatory therapies for atherosclerosis

M Bäck, GK Hansson - Nature Reviews Cardiology, 2015 - nature.com
The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …

The link between inflammatory disorders and coronary heart disease: a look at recent studies and novel drugs in development

H Teague, NN Mehta - Current atherosclerosis reports, 2016 - Springer
Inflammation is a critical component in the development of coronary heart disease (CHD),
specifically in the process of atherogenesis. Human translational and preclinical studies …

Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition

A Munjal, R Khandia - Advances in protein chemistry and structural biology, 2020 - Elsevier
The term atherosclerosis refers to the condition of deposition of lipids and other substances
in and on the artery walls, called as plaque that restricts the normal blood flow. The plaque …

[HTML][HTML] Anti-inflammatory strategies in atherosclerosis

H Bugger, A Zirlik - Hämostaseologie, 2021 - thieme-connect.com
Atherosclerotic vascular disease and its related complications are the major cause of
mortality in Western societies. Atherosclerosis is a chronic inflammatory disease of the …

Novel anti-inflammatory strategies in atherosclerosis

FM van der Valk, DF van Wijk… - Current opinion in …, 2012 - journals.lww.com
Anti-inflammatory therapies hold great promise in cardiovascular prevention regimens;
however, atherosclerosis is a chronic disease, and systemic long-term use of anti …

Insights into the Role of Inflammation in the Management of Atherosclerosis

VZ Rocha, FH Rached, MH Miname - Journal of Inflammation …, 2023 - Taylor & Francis
Atherosclerosis is the biological basis of ischemic heart disease and ischemic stroke, the
leading causes of death in the world. After decades of studies, the understanding of …

Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond

C Weber, AJR Habenicht… - European heart …, 2023 - academic.oup.com
This review based on the ESC William Harvey Lecture in Basic Science 2022 highlights
recent experimental and translational progress on the therapeutic targeting of the …

[HTML][HTML] Inflammatory mediators in atherosclerotic vascular remodeling

BR Evans, A Yerly, EPC van der Vorst… - Frontiers in …, 2022 - frontiersin.org
Atherosclerotic vascular disease remains the most common cause of ischemia, myocardial
infarction, and stroke. Vascular function is determined by structural and functional properties …