[HTML][HTML] Therapeutic approaches to drug targets in atherosclerosis

PG Jamkhande, PG Chandak, SC Dhawale… - Saudi Pharmaceutical …, 2014 - Elsevier
Non-communicable diseases such as cancer, atherosclerosis and diabetes are responsible
for major social and health burden as millions of people are dying every year. Out of which …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection

PM Ridker - Circulation research, 2016 - Am Heart Assoc
Plasma levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP)
predict vascular risk with an effect estimate as large as that of total or high-density …

[HTML][HTML] Targeting inflammatory pathways in cardiovascular disease: the inflammasome, interleukin-1, interleukin-6 and beyond

P Libby - Cells, 2021 - mdpi.com
Recent clinical trials have now firmly established that inflammation participates causally in
human atherosclerosis. These observations point the way toward novel treatments that add …

[HTML][HTML] Expanded network of inflammatory markers of atherogenesis: where are we now?

SH Abbasi, MA Boroumand - The open cardiovascular medicine …, 2010 - ncbi.nlm.nih.gov
Inflammatory biomarkers play a pivotal role in atherosclerotic lesions. The plasma levels of
these markers are predictive of adverse outcomes such as myocardial infarction and …

[HTML][HTML] The role of pro-Inflammatory cytokines in the pathogenesis of cardiovascular disease

H Zhang, NS Dhalla - International Journal of Molecular Sciences, 2024 - mdpi.com
With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Inflammation and cardiovascular disease: from pathogenesis to therapeutic target

E Golia, G Limongelli, F Natale, F Fimiani… - Current atherosclerosis …, 2014 - Springer
Atherosclerosis represents the most common pathological substrate of coronary heart
disease (CHD), and the characterization of the disease as a chronic low-grade inflammatory …

[HTML][HTML] Inflammation and cardiovascular disease

CG Katsiari, DP Bogdanos, LI Sakkas - World Journal of Translational …, 2019 - wjgnet.com
Cardiovascular disease (CVD) has been associated with the so-called traditional risk
factors, such as hypertension, hypercholesterolemia and cigarette smoking. Chronic …

Therapeutic strategies for atherosclerosis and atherothrombosis: past, present and future

C Weber, L Badimon, F Mach… - Thrombosis and …, 2017 - thieme-connect.com
Even two centuries after they were first described, atherosclerosis and atherothrombosis
remain among the leading causes of death worldwide. Over the last decades it has become …

[HTML][HTML] Cytokines as therapeutic targets for cardio-and cerebrovascular diseases

L Liberale, S Ministrini, F Carbone, GG Camici… - Basic Research in …, 2021 - Springer
Despite major advances in prevention and treatment, cardiac and cerebral atherothrombotic
complications still account for substantial morbidity and mortality worldwide. In this context …