Incidence and mortality rates for cardiovascular disease are declining, but it still remains a
major cause of morbidity and mortality. Drug treatments to slow the progression of …

Atherosclerosis is the pathological process that underlies the development of cardiovascular
disease, a leading cause of mortality. Atherosclerotic plaque formation is driven by the …

The cytokines are multipotent mediators of inflammation and immunity that can affect key
functions of vascular wall cells. Growing evidence suggests that cytokines participate as …

This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to
monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the …

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture,
vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute …

Inflammatory pathways drive atherogenesis and link conventional risk factors to
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …

Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and
vasoconstriction, elevated reactive oxygen species (ROS), and inflammatory factors, as well …

Atherosclerosis is no longer considered a disorder due to abnormalities in lipid metabolism.
In fact, the inciting event of atherosclerosis is likely an inflammatory insult that occurs …

Atherosclerosis is a dynamic, pathogenic process in the artery wall, with potential adverse
outcome for the host. Acute events such as myocardial infarction and ischemic stroke often …

The pathobiology of atherosclerosis and its current and potential future treatments are
summarized, with a spotlight on three central cell types involved:(i) endothelial cells …