Studies focusing on possible genotoxic effects of excess fluoride are contradictory and
inconclusive. Currently, studies have reported a probable link to oxidative stress, DNA …

Fluoride compounds are abundant and widely distributed in the environment at a variety of
concentrations. Further, fluoride induces toxic effects in target organs such as the liver. In …

Humans are primarily exposed to fluoride (Fl), a widespread environmental pollutant, via
contaminated drinking water and foodstuffs. The aim of this study was to examine whether …

Fluoride (F) can induce changes in the expression of several liver proteins. It is suggested
that these changes are dose-and time-dependent. The objective of this study was to analyze …

The role of oxidative stress in fluoride hepatotoxicity was investigated. Three groups of eight
4-week-old Wistar rats were given 50, 100, and 150 mg NaF/L in their drinking water for …

Objective To investigate the effects of fluoride on lipid peroxidation, DNA damage and
apoptosis in human embryo hepatocyte L-02 cells. Methods Lipid peroxide (LPO) level …

AIM: To study the effect of fluoride on oxidative stress, DNA damage and apoptosis as well
as cell cycle of rat oral mucosal cells and hepatocytes. METHODS: Ten male SD rats …

This article focuses on lipid peroxidation and antioxidant defense system. Fluoride is of great
importance to the health and well being of humans and animals. The major source of …

Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering
the strong evidence for a relationship between genetic damage and carcinogenesis, to …

Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …