Fluoride-induced oxidative stress is involved in the morphological damage and dysfunction of liver in female mice

B Zhou, J Zhao, J Liu, J Zhang, J Li, H Wang - Chemosphere, 2015 - Elsevier
Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …

Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride

J Manivannan, S Sinha, M Ghosh… - Mutation Research/Genetic …, 2013 - Elsevier
Fluoride compounds are naturally present in soil, water and food. The objective of this study
was to investigate the genotoxic and oxidative damage induced by chronic fluoride …

Induction of pathological changes and impaired expression of cytokines in developing female rat spleen after chronic excess fluoride exposure

J Liu, H Wang, W Zhao, X Li, L Lin… - … and industrial health, 2019 - journals.sagepub.com
This study was designed to investigate the effects of excessive fluoride on spleen toxicity.
Twenty-four healthy female rats were randomly divided into two groups, each of 12 rats …

Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: a possible mechanism

VV Kanagaraj, L Panneerselvam, V Govindarajan… - Biofactors, 2015 - Wiley Online Library
Fluoride induced hepatotoxicity has been extensively studied in both humans and animals.
However, the mechanism underlying in the hepatotoxicity of experimental fluorosis remains …

Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data

S Chouhan, SJS Flora - Toxicology, 2008 - Elsevier
The mechanism underlying the toxicity of fluoride still remains unknown. To investigate the
effects of different doses of fluoride on blood and tissue oxidative stress and apoptosis, we …

N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes

K Pawłowska-Góral, E Kurzeja, M Stec - Toxicology in Vitro, 2013 - Elsevier
Fluoride induces the overproduction of free radicals, which might in turn affect various
biochemical parameters. Therefore, the aim of this study was to elucidate the role of N …

Gene expression and alterations of antioxidant enzymes in spleen of rats exposed to fluoride

A Shashi, S Thakur - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
Background Fluorosis is a slow and progressive process causing metabolic, functional and
structural damages affecting many tissues particularly musculoskeletal, dental systems …

Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats

A de Lima Leite… - Human & …, 2007 - journals.sagepub.com
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there
has been some speculation that excess fluoride could cause an impact on genome integrity …

Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs

XA Zhan, M Wang, ZR Xu, WF Li, JX Li - Archives of toxicology, 2006 - Springer
Abstract Sixteen barrows (Duroc× Landrace× Yorkshire) were randomly divided into two
groups, each consisting eight pigs. The groups received the same basal diet supplemented …

Dietary calcium alleviates fluorine-induced liver injury in rats by mitochondrial apoptosis pathway

H Li, Z Hao, L Wang, J Yang, Y Zhao, X Cheng… - … Trace Element Research, 2022 - Springer
Excessive fluoride (F) exposure can lead to liver damage; moreover, recent studies found
that the addition of appropriate calcium (Ca) can alleviate the symptom of skeletal fluorosis …