Fluoride-induced oxidative stress is involved in the morphological damage and dysfunction of liver in female mice
B Zhou, J Zhao, J Liu, J Zhang, J Li, H Wang - Chemosphere, 2015 - Elsevier
Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …
Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride
Fluoride compounds are naturally present in soil, water and food. The objective of this study
was to investigate the genotoxic and oxidative damage induced by chronic fluoride …
was to investigate the genotoxic and oxidative damage induced by chronic fluoride …
Induction of pathological changes and impaired expression of cytokines in developing female rat spleen after chronic excess fluoride exposure
J Liu, H Wang, W Zhao, X Li, L Lin… - … and industrial health, 2019 - journals.sagepub.com
This study was designed to investigate the effects of excessive fluoride on spleen toxicity.
Twenty-four healthy female rats were randomly divided into two groups, each of 12 rats …
Twenty-four healthy female rats were randomly divided into two groups, each of 12 rats …
Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: a possible mechanism
VV Kanagaraj, L Panneerselvam, V Govindarajan… - Biofactors, 2015 - Wiley Online Library
Fluoride induced hepatotoxicity has been extensively studied in both humans and animals.
However, the mechanism underlying in the hepatotoxicity of experimental fluorosis remains …
However, the mechanism underlying in the hepatotoxicity of experimental fluorosis remains …
Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data
S Chouhan, SJS Flora - Toxicology, 2008 - Elsevier
The mechanism underlying the toxicity of fluoride still remains unknown. To investigate the
effects of different doses of fluoride on blood and tissue oxidative stress and apoptosis, we …
effects of different doses of fluoride on blood and tissue oxidative stress and apoptosis, we …
N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes
K Pawłowska-Góral, E Kurzeja, M Stec - Toxicology in Vitro, 2013 - Elsevier
Fluoride induces the overproduction of free radicals, which might in turn affect various
biochemical parameters. Therefore, the aim of this study was to elucidate the role of N …
biochemical parameters. Therefore, the aim of this study was to elucidate the role of N …
Gene expression and alterations of antioxidant enzymes in spleen of rats exposed to fluoride
A Shashi, S Thakur - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
Background Fluorosis is a slow and progressive process causing metabolic, functional and
structural damages affecting many tissues particularly musculoskeletal, dental systems …
structural damages affecting many tissues particularly musculoskeletal, dental systems …
Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats
A de Lima Leite… - Human & …, 2007 - journals.sagepub.com
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there
has been some speculation that excess fluoride could cause an impact on genome integrity …
has been some speculation that excess fluoride could cause an impact on genome integrity …
Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs
XA Zhan, M Wang, ZR Xu, WF Li, JX Li - Archives of toxicology, 2006 - Springer
Abstract Sixteen barrows (Duroc× Landrace× Yorkshire) were randomly divided into two
groups, each consisting eight pigs. The groups received the same basal diet supplemented …
groups, each consisting eight pigs. The groups received the same basal diet supplemented …
Dietary calcium alleviates fluorine-induced liver injury in rats by mitochondrial apoptosis pathway
H Li, Z Hao, L Wang, J Yang, Y Zhao, X Cheng… - … Trace Element Research, 2022 - Springer
Excessive fluoride (F) exposure can lead to liver damage; moreover, recent studies found
that the addition of appropriate calcium (Ca) can alleviate the symptom of skeletal fluorosis …
that the addition of appropriate calcium (Ca) can alleviate the symptom of skeletal fluorosis …