Background Nebivolol is a new β 1-selective adrenergic receptor antagonist with a direct
vasorelaxant effect that involves activation of the l-arginine–nitric oxide (NO) pathway …

Nebivolol is a new selective beta 1‐adrenoceptor antagonist with nitric oxide (NO)–
releasing properties. In the present study we have analyzed whether nebivolol affects the …

Background Vascular endothelial dysfunction may predict future atherosclerosis. Hence, an
antihypertensive agent that reverses endothelial dysfunction and lowers blood pressure …

Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct
vasodilator effect attributed to the action on vascular nitric oxide (NO). This study aimed to …

The mechanisms for the vascular actions of vasodilatory β-blockers remain undetermined.
For some kinds of β-blockers, the involvement of nitric oxide (NO) has been suggested. We …

Objective: Since the effects of angiotensin II receptor antagonism on arterial function in nitric
oxide (NO)-deficient hypertension are unknown, we investigated the influence of losartan …

Long-term propranolol treatment reduces arterial blood pressure in hypertensive individuals
mainly by reducing peripheral vascular resistance, but mechanisms underlying their …

The objective of this study was to examine the effects of long-term antihypertensive therapy
on blood pressure and vascular responses of resistance arteries during prolonged inhibition …

Background Endothelial cell (EC) dysfunction contributes to hypertension and mechanisms
of atherosclerosis. Agents that improve EC function may provide vascular protection …

Nebivolol is known as a highly selective β1-adrenoceptor antagonist. Based on the reported
vasodilator effect of nebivolol, we examined the cellular mechanisms by which the drug …