Nebivolol is a highly selective β 1 adrenoceptor blocker with additional vasodilating
properties. Although it has been shown that the nebivolol-induced vasorelaxation is nitric …

The effects of the administration of either the angiotensin converting enzyme (ACE) inhibitor,
quinapril (10 mg/kg/day, orally), or the calcium antagonist, diltiazem (100 mg/kg/day, orally) …

Nebivolol, a racemic mixture of (S, R, R, R) and (R, S, S, S) enantiomers, is the most β 1-
selective adrenoceptor antagonist currently available for clinical use. However, its …

High salt diet is often associated with increases in blood pressure, and the state of activation
of endothelium-dependent vascular relaxation pathways is critical under these conditions …

Endothelial dysfunction is a common problem associated with hypertension and is
considered a precursor to the development of micro-and macro-vascular complications. The …

Objective Endothelium-dependent vasodilation is attenuated in humans and experimental
hypertension models, and this phenomenon may be largely due to decreased release or …

Endothelium-derived nitric oxide (NO) is an important gas molecule in the regulation of
vascular tone and arterial pressure. It has been considered that endothelial dysfunction with …

Background: The antihypertensive activity of beta-blockers generally increases during the
first 6 to 8 weeks of treatment; however, no study has systematically assessed whether blood …

Background Although there is overwhelming evidence that hypertension promotes
atherosclerosis, the relative contribution and/or interaction of vasoactive and hemodynamic …

Background: The renin-angiotensin-aldosterone system and oxidative stress play a major
role in the pathogenesis of hypertension. Methods: We examined the effects of simvastatin …