Chaperone-mediated autophagy (CMA) contributes to the lysosomal degradation of a
selective subset of proteins. Selectivity lies in the chaperone heat shock cognate 71 kDa …

Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …

Autophagy, a major degradation process for long-lived and aggregate-prone proteins,
affects various human processes, such as development, immunity, cancer, and …

Many neurodegenerative disorders are characterized by the aberrant accumulation of
aggregate-prone proteins. Alzheimer's disease (AD) is associated with the buildup of β …

Degradation of intracellular components in lysosomes, generically known as autophagy, can
occur through different pathways. This review discusses chaperone-mediated autophagy …

Chaperone-mediated autophagy (CMA) contributes to selective degradation of individual
soluble proteins in lysosomes. Unique to this type of autophagy is the fact that proteins reach …

Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis,
has recently been the focus of numerous human diseases and conditions, such as aging …

Autophagy is a major protein degradation pathway that is essential for stress-induced and
constitutive protein turnover. Accumulated evidence has demonstrated that amyloid-β (Aβ) …

Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation
pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major …

Chaperone-mediated autophagy (CMA) is a multistep process that involves selective
degradation and digestion of a pool of soluble cytosolic proteins in lysosomes. Cytosolic …