Group A Streptococcus (GAS) evades polymorphonuclear leukocyte (PMN) phagocytosis
and killing to cause human disease, including pharyngitis and necrotizing fasciitis (flesh …

Neutrophils are a critical component of human innate host defense and efficiently kill the
vast majority of invading microorganisms. However, bacterial pathogens such as group A …

The molecular basis for bacterial responses to host signals during natural infections is
poorly understood. The gram-positive bacterial pathogen group A Streptococcus (GAS) …

Streptococcus pyogenes, also known as Group A Streptococcus (GAS), is a Gram-positive
human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide …

ABSTRACT Group A Streptococcus (GAS) causes a range of diseases in humans, from mild
noninvasive infections to severe invasive infections. The molecular basis for the varying …

Many pathogenic bacteria produce extracellular DNase, but the benefit of this enzymatic
activity is not understood. For example, all strains of the human bacterial pathogen group A …

Abstract Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for
which a commercial vaccine for humans is not available. Employing the advantages of high …

Group B Streptococcus (GBS) is a multiserotype bacterial pathogen representing a major
cause of life-threatening infections in newborns. To develop a broadly protective vaccine, we …

Group A streptococci (GAS) can cause a wide variety of human infections ranging from
asymptomatic colonization to life-threatening invasive diseases. Although antibiotic …

Analysis of three group A Streptococcus genomes (serotypes M1, M3, and M18) recently
identified four previously undescribed genes that encode extracellular proteins. Each of …