PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence

E Falleti, C Fabris, S Cmet, A Cussigh… - Liver …, 2011 - Wiley Online Library
Background and aim: The PNPLA3 rs738409 C> G polymorphism has been found to be
strongly associated with non‐alcoholic fatty liver disease and with alcoholic liver disease …

Correlation between PNPLA3 rs738409 polymorphism and hepatocellular carcinoma: a meta-analysis of 10,330 subjects

Z Huang, X Guo, G Zhang, L Liang… - … International journal of …, 2019 - journals.sagepub.com
Purpose: The correlation between patatin-like phospholipase domain-containing protein 3
(PNPLA3) rs738409 polymorphism and hepatocellular carcinoma was investigated by …

PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis

E Guyot, A Sutton, P Rufat, C Laguillier, A Mansouri… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Several studies have reported an association between the genetic
variant rs738409 (G) in the PNPLA3 gene and the risk of cirrhosis in various liver diseases …

[PDF][PDF] Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta‐analysis of individual participant data

E Trépo, P Nahon, G Bontempi, L Valenti, E Falleti… - …, 2014 - Wiley Online Library
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries.
Although several clinical factors have been identified, many individuals never develop HCC …

The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis

HD Nischalke, C Berger, C Luda, T Berg, T Müller… - PLoS …, 2011 - journals.plos.org
Background An isoleucine> methionine mutation at position 148 in the PNPLA3 gene (p.
I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in …

Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction

MM Hassan, A Kaseb, CJ Etzel… - Molecular …, 2013 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in
Western countries. Genome‐wide association studies had reported that a variation in the …

PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma

L Valenti, BM Motta, G Soardo, M Iavarone, B Donati… - PLoS …, 2013 - journals.plos.org
Background & Aims Aim of this study was to evaluate whether the PNPLA3 I148M
polymorphism, previously associated with hepatocellular carcinoma (HCC) risk, influences …

The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis

JH Shen, YL Li, D Li, NN Wang, L Jing… - Journal of lipid …, 2015 - ASBMB
The human patatin-like phospholipase domain-containing-3 (PNPLA3) gene rs738409 C> G
polymorphism is associated with several types of liver disease. The aim of this meta-analysis …

Carriage of the PNPLA3 rs738409 C> G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

YL Liu, GL Patman, JBS Leathart, AC Piguet… - Journal of …, 2014 - Elsevier
Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …

Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection

M Sato, N Kato, R Tateishi, R Muroyama… - Hepatology …, 2014 - Wiley Online Library
Aim The PNPLA3 rs738409 C> G polymorphism (encoding for I148M) has recently been
identified as a susceptibility factor for steatosis‐mediated liver damage. We evaluated the …