CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10
X Huang, BP Wu, D Nguyen, YT Liu… - Human molecular …, 2018 - academic.oup.com
Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal
dominant Parkinson Disease (PD) and Amyotrophic Lateral Sclerosis/Frontotemporal …
dominant Parkinson Disease (PD) and Amyotrophic Lateral Sclerosis/Frontotemporal …
Mitochondrial CHCHD-containing proteins: physiologic functions and link with neurodegenerative diseases
ZD Zhou, WT Saw, EK Tan - Molecular neurobiology, 2017 - Springer
The coiled-coil-helix-coiled-coil-helix domain (CHCHD)-containing proteins are
evolutionarily conserved nucleus-encoded small mitochondrial proteins with important …
evolutionarily conserved nucleus-encoded small mitochondrial proteins with important …
Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
H Meng, C Yamashita, K Shiba-Fukushima… - Nature …, 2017 - nature.com
Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To
understand the physiological and pathological roles of CHCHD2, we manipulated the …
understand the physiological and pathological roles of CHCHD2, we manipulated the …
Mitochondrial CHCHD2: disease-associated mutations, physiological functions, and current animal models
TR Kee, P Espinoza Gonzalez, JL Wehinger… - Frontiers in aging …, 2021 - frontiersin.org
Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …
Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?
A Ikeda, Y Imai, N Hattori - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and Coiled-coil-helix-
coiled-coil-helix domain containing 10 (CHCHD10) are mitochondrial proteins that are …
coiled-coil-helix domain containing 10 (CHCHD10) are mitochondrial proteins that are …
CHCHD2 harboring Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2
T Cornelissen, M Spinazzi, S Martin… - Human Molecular …, 2020 - academic.oup.com
The T61I mutation in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), a
protein residing in the mitochondrial intermembrane space (IMS), causes an autosomal …
protein residing in the mitochondrial intermembrane space (IMS), causes an autosomal …
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2
Mutations in the mitochondrial protein CHCHD2 cause autosomal dominant Parkinson's
disease characterized by the preferential loss of substantia nigra dopamine (DA) neurons …
disease characterized by the preferential loss of substantia nigra dopamine (DA) neurons …
CHCHD10 is involved in the development of Parkinson's disease caused by CHCHD2 loss-of-function mutation p. T61I
C Mao, H Wang, H Luo, S Zhang, H Xu, S Zhang… - Neurobiology of …, 2019 - Elsevier
Previously we identified the p. Thr61Ile mutation in coiled-coil-helix-coiled-coil-helix domain
containing 2 (CHCHD2) in a Chinese family with autosomal dominant Parkinson's disease …
containing 2 (CHCHD2) in a Chinese family with autosomal dominant Parkinson's disease …
CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy
MK Shammas, TH Huang… - Biochemical Society …, 2023 - portlandpress.com
In the last decade, dominant mutations in the mitochondrial protein CHCHD10 (p. R15L and
p. S59L) and its paralog CHCHD2 (p. T61I) were shown to cause familial amyotrophic lateral …
p. S59L) and its paralog CHCHD2 (p. T61I) were shown to cause familial amyotrophic lateral …
Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation
TR Kee, JL Wehinger, PE Gonzalez… - Human molecular …, 2022 - academic.oup.com
Abstract Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a
mitochondrial protein that plays important roles in cristae structure, oxidative …
mitochondrial protein that plays important roles in cristae structure, oxidative …