Role of extracellular vesicles in amyotrophic lateral sclerosis

D Ferrara, L Pasetto, V Bonetto, M Basso - Frontiers in neuroscience, 2018 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults
and primarily targets upper and lower motor neurons. The progression of the disease is …

Extracellular vesicles in amyotrophic lateral sclerosis

G McCluskey, KE Morrison, C Donaghy, F Rene… - Life, 2022 - mdpi.com
Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease and is the most
common adult motor neuron disease. The disease pathogenesis is complex with the …

Recent advances in extracellular vesicles in amyotrophic lateral sclerosis and emergent perspectives

GJM Afonso, C Cavaleiro, J Valero, SI Mota, E Ferreiro - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease
characterized by the progressive death of motor neurons, leading to paralysis and death. It is …

Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers

D Gagliardi, N Bresolin, GP Comi, S Corti - Cellular and Molecular Life …, 2021 - Springer
Extracellular vesicles (EVs) are small reservoirs of different molecules and important
mediators of cell-to-cell communication. As putative vehicles of misfolded protein …

[HTML][HTML] Pathogenic extracellular vesicle (EV) signaling in amyotrophic lateral sclerosis (ALS)

G Kim, X Chen, Y Yang - Neurotherapeutics, 2022 - Elsevier
Extracellular vesicles (EVs), once considered a pathway for cells to remove waste, have now
emerged as an important mechanism for intercellular communication. EVs are particularly …

Extracellular vesicles as potential biomarkers in amyotrophic lateral sclerosis

M Barbo, M Ravnik-Glavač - Genes, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …

Pathological proteins are transported by extracellular vesicles of sporadic amyotrophic lateral sclerosis patients

D Sproviero, S La Salvia, M Giannini… - Frontiers in …, 2018 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive adult-onset neurodegenerative disease,
that affects cortical, bulbar and spinal motor neurons, and it is considered a proteinopathy, in …

Extracellular vesicles in serum and central nervous system tissues contain microRNA signatures in sporadic amyotrophic lateral sclerosis

T Lo, C Figueroa-Romero, J Hur, C Pacut… - Frontiers in Molecular …, 2021 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a terminalneurodegenerative disease. Clinical and
molecular observations suggest that ALS pathology originates at a single site and spreads …

Clinical implications of extracellular vesicles in neurodegenerative diseases

A Vinaiphat, SK Sze - Expert Review of Molecular Diagnostics, 2019 - Taylor & Francis
ABSTRACT Introduction: Extracellular vesicles (EVs) released by neural cells play a crucial
role in intracellular communication in both physiological and pathological states. Recent …

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

L Pasetto, S Callegaro, A Corbelli, F Fiordaliso… - Molecular …, 2021 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron
disease for which currently there is no effective treatment. There is an urgent need to identify …