In normal vascular physiology, NO plays a key role to maintain the vascular wall in a
quiescent state by inhibition of inflammation, cellular proliferation, and thrombosis. This is in …

The discovery of nitric oxide (NO) as a crucial endothe-lium-derived molecule for vascular
relaxation and the recognition of the endothelium as more than a passive interface between …

The vascular endothelium secretes factors that not only modulate blood vessel tone, but also
participate in the development and progression of atherosclerosis through their effects on …

The endothelium plays a key role in vascular homeostasis through the release of a variety of
autocrine and paracrine substances, the best characterized being nitric oxide. A healthy …

There are few discoveries with the magnitude of the impact that NO has had on biology
during the 25 years since its discovery. There is hardly a disease today not associated with …

Endothelial dysfunction (ED) in the setting of cardiovascular risk factors such as
hypercholesterolemia, hypertension, diabetes mellitus, chronic smoking as well as in …

The vascular endothelium plays a crucial role in the regulation of vascular homeostasis and
in preventing the initiation and progress of cardiovascular disease by controlling mechanical …

The endothelium plays an important role in the maintenance of vascular homeostasis.
Central to this role is the endothelial production of nitric oxide (NO), synthesized by the …

Endothelial dysfunction is an independent predictor of cardiovascular risk. It is found with
aging, and in many conditions associated with increased cardiovascular risk such as …

The endothelium regulates vascular tone, platelet activity, leukocyte adhesion, and
angiogenesis by producing nitric oxide and other regulatory factors. Risk factors decrease …