Far from simply lining the inner surface of blood vessels, the cellular monolayer that
comprises the endothelium is a highly active organ that regulates vascular tone. In health …

Vascular endothelium plays a key role in the local regulation of vascular tone and vascular
architecture by release of vasodilator and vasoconstrictor substances, as well as factors with …

The vascular endothelium contributes to and is affected by inflammatory processes.
Disturbance of the endothelium's morphologic and functional integrity in response to …

The vascular endothelium is the site of formation of several powerful mediators. One of these
is NO, a chemically unstable radical formed by enzymatic conversion of L-arginine in the …

Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of
vascular disease. NO has a number of intracellular effects that lead to vasorelaxation …

In the past decade, the importance of the vascular endothelium as a multifunctional regulator
of vascular smooth muscle physiology and pathophysiology has been appreciated. Indeed …

The vascular endothelium is involved in the release of various vasodilators, including nitric
oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor, as well as …

Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is
certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to …

Since its discovery, endothelium-derived nitric oxide (NO) has become one of the most
intensely investigated molecules in the field of cardiovascular physiology. Although initial …

The endothelium plays a crucial role in the process of atherosclerotic disease by its
regulatory functions on the vasculature, such as control of vasomotor tone, local hemostasis …