Macrophages serve as a first line of defense against infection with the facultative
intracellular pathogen, Cryptococcus neoformans (Cn). However, the ability of these innate …

The human fungal pathogen Cryptococcus neoformans is able to rapidly and effectively
adapt to varying conditions, favoring its survival in the environment and in the infected host …

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature …

The ability of Cryptococcus neoformans to cause disease in humans varies significantly
among strains with highly related genotypes. In general, environmental isolates of …

We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …

Highlights•Both host and environmental signals entail cryptococcal morphotype
heterogeneity.•Diverse morphotypes are coordinated with saprophytic and pathogenic …

Microorganisms that live in fluctuating environments must constantly adapt their behavior to
survive. The host constitutes an important microenvironment in opportunistic and primary …

Macrophages have a central role in the pathogenesis of cryptococcosis since they are an
important line of defense, serve as a site for fungal replication, and also can contribute to …

Although several virulence factors and associated genes have been identified, the
mechanisms that allow Cryptococcus neoformans to adapt during chronic infection and to …

The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …