Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

A Doller, J Pfeilschifter, W Eberhardt - Cellular signalling, 2008 - Elsevier
During the last decade evidence from numerous studies has been accumulated
demonstrating that posttranscriptional gene regulation including mRNA turnover and …

Nuclear HuR accumulation through phosphorylation by Cdk1

HH Kim, K Abdelmohsen, A Lal… - Genes & …, 2008 - genesdev.cshlp.org
A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in
response to stress and proliferative signals, where it stabilizes or modulates the translation …

[HTML][HTML] Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR)

S Lu, JL Mott, DD Harrison-Findik - Journal of Biological Chemistry, 2015 - ASBMB
Iron is implicated in fatty liver disease pathogenesis. The human hepcidin gene, HAMP, is
the master switch of iron metabolism. The aim of this study is to investigate the regulation of …

[HTML][HTML] Identification of small-molecule inhibitors of the HuR/RNA interaction using a fluorescence polarization screening assay followed by NMR validation

Z Wang, A Bhattacharya, DN Ivanov - PloS one, 2015 - journals.plos.org
The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription
factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in …

Regulation of HuR structure and function by dihydrotanshinone-I

P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …

High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells

A Doller, C Winkler, I Azrilian, S Schulz… - …, 2011 - academic.oup.com
Overexpression of the messenger RNA (mRNA)-binding protein HuR is an important feature
of many tumors and in most cases correlates with a high-grade malignancy. Since …

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

W Dai, G Zhang, EV Makeyev - Nucleic acids research, 2012 - academic.oup.com
RNA-binding protein HuR modulates the stability and translational efficiency of messenger
RNAs (mRNAs) encoding essential components of the cellular proliferation, growth and …

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes

A Doller, S Schulz, J Pfeilschifter… - Nucleic acids …, 2013 - academic.oup.com
The role of the mRNA-binding protein human antigen R (HuR) in stabilization and
translation of AU-rich elements (ARE) containing mRNAs is well established. However, the …

[HTML][HTML] Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites

PJ Uren, SC Burns, J Ruan, KK Singh, AD Smith… - Journal of Biological …, 2011 - ASBMB
The ubiquitously expressed RNA-binding protein Hu antigen R (HuR) or ELAVL1 is
implicated in a variety of biological processes as well as being linked with a number of …

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

M Pabis, GM Popowicz, R Stehle… - Nucleic acids …, 2019 - academic.oup.com
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …