miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
K Abdelmohsen, S Srikantan… - Proceedings of the …, 2008 - National Acad Sciences
Gene expression is potently regulated through the action of RNA-binding proteins (RBPs)
and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The …
and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The …
[HTML][HTML] Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells
F Baldan, C Mio, L Allegri, K Conzatti, B Toffoletto… - Oncotarget, 2016 - ncbi.nlm.nih.gov
RNA binding proteins (RBPs) play a central role in cell physiology and pathology. Among
them, HuR is a nuclear RBP, which shuttles to the cytoplasm to allow its RNA targets …
them, HuR is a nuclear RBP, which shuttles to the cytoplasm to allow its RNA targets …
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis
Interactions between RNA binding proteins (RBPs) and genes are not well understood,
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions …
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions …
[HTML][HTML] HuR posttranscriptionally regulates early growth response-1 (Egr-1) expression at the early stage of T cell activation
T cell activation depends on appropriate and precise regulation of gene expression. Here
we find that rapidly translocated RNA-binding protein HuR, forms messenger …
we find that rapidly translocated RNA-binding protein HuR, forms messenger …
Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer
HH Woo, Y Zhou, X Yi, CL David, W Zheng… - Oncogene, 2009 - nature.com
The role of RNA-binding proteins in cancer biology is recognized increasingly. The
nucleocytoplasmic shuttling and AU-rich RNA-binding protein HuR stabilizes several cancer …
nucleocytoplasmic shuttling and AU-rich RNA-binding protein HuR stabilizes several cancer …
[HTML][HTML] Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR
R Pullmann, M Juhaszova, IL De Silanes… - Journal of Biological …, 2005 - ASBMB
In dividing cells, the RNA-binding protein HuR associates with and stabilizes labile mRNAs
encoding proliferative proteins, events that are linked to the increased cytoplasmic presence …
encoding proliferative proteins, events that are linked to the increased cytoplasmic presence …
The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack
Glioblastoma (GBM) is a malignant and aggressive brain tumor with a median survival of∼
15 months. Resistance to treatment arises from the extensive cellular and molecular …
15 months. Resistance to treatment arises from the extensive cellular and molecular …
Posttranscriptional regulation of cancer traits by HuR
K Abdelmohsen, M Gorospe - Wiley Interdisciplinary Reviews …, 2010 - Wiley Online Library
Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …
[HTML][HTML] RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
SM García-Mauriño, F Rivero-Rodríguez… - Frontiers in molecular …, 2017 - frontiersin.org
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs)
that determine mRNA fate, thereby influencing multiple cellular functions across biological …
that determine mRNA fate, thereby influencing multiple cellular functions across biological …
Androgen Regulates the Level and Subcellular Distribution of the AU-Rich Ribonucleic Acid-Binding Protein HuR Both in Vitroand in Vivo
LG Sheflin, W Zhang, SW Spaulding - Endocrinology, 2001 - academic.oup.com
HuR, a member of the ELAV family of AU-rich RNA-binding proteins, is present in a variety of
tissues and is directly involved in stabilizing labile AU-rich messenger RNAs. We have found …
tissues and is directly involved in stabilizing labile AU-rich messenger RNAs. We have found …