miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

K Abdelmohsen, S Srikantan… - Proceedings of the …, 2008 - National Acad Sciences
Gene expression is potently regulated through the action of RNA-binding proteins (RBPs)
and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The …

[HTML][HTML] Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells

F Baldan, C Mio, L Allegri, K Conzatti, B Toffoletto… - Oncotarget, 2016 - ncbi.nlm.nih.gov
RNA binding proteins (RBPs) play a central role in cell physiology and pathology. Among
them, HuR is a nuclear RBP, which shuttles to the cytoplasm to allow its RNA targets …

Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis

MM Gubin, R Calaluce, JW Davis, JD Magee… - Cell Cycle, 2010 - Taylor & Francis
Interactions between RNA binding proteins (RBPs) and genes are not well understood,
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions …

[HTML][HTML] HuR posttranscriptionally regulates early growth response-1 (Egr-1) expression at the early stage of T cell activation

Z Mou, J You, Q Xiao, Y Wei, J Yuan, Y Liu, G Brewer… - FEBS letters, 2012 - Elsevier
T cell activation depends on appropriate and precise regulation of gene expression. Here
we find that rapidly translocated RNA-binding protein HuR, forms messenger …

Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer

HH Woo, Y Zhou, X Yi, CL David, W Zheng… - Oncogene, 2009 - nature.com
The role of RNA-binding proteins in cancer biology is recognized increasingly. The
nucleocytoplasmic shuttling and AU-rich RNA-binding protein HuR stabilizes several cancer …

[HTML][HTML] Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR

R Pullmann, M Juhaszova, IL De Silanes… - Journal of Biological …, 2005 - ASBMB
In dividing cells, the RNA-binding protein HuR associates with and stabilizes labile mRNAs
encoding proliferative proteins, events that are linked to the increased cytoplasmic presence …

The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack

A Guha, S Waris, LB Nabors, N Filippova… - Advanced drug delivery …, 2022 - Elsevier
Glioblastoma (GBM) is a malignant and aggressive brain tumor with a median survival of∼
15 months. Resistance to treatment arises from the extensive cellular and molecular …

Posttranscriptional regulation of cancer traits by HuR

K Abdelmohsen, M Gorospe - Wiley Interdisciplinary Reviews …, 2010 - Wiley Online Library
Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

[HTML][HTML] RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate

SM García-Mauriño, F Rivero-Rodríguez… - Frontiers in molecular …, 2017 - frontiersin.org
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs)
that determine mRNA fate, thereby influencing multiple cellular functions across biological …

Androgen Regulates the Level and Subcellular Distribution of the AU-Rich Ribonucleic Acid-Binding Protein HuR Both in Vitroand in Vivo

LG Sheflin, W Zhang, SW Spaulding - Endocrinology, 2001 - academic.oup.com
HuR, a member of the ELAV family of AU-rich RNA-binding proteins, is present in a variety of
tissues and is directly involved in stabilizing labile AU-rich messenger RNAs. We have found …