Background Obesity is associated with increased levels of leptin. The mitogenic actions of
leptin have been identified in various cell types. Because obesity may be a risk factor for …

INTRODUCTION: Leptin, a protein produced by adipocytes, is an important signaling
molecule in energy regulation and food intake. Many obese patients have leptin resistance …

Background and aims Obesity is a major risk factor for the development of colon cancer.
Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels …

Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …

Leptin, which is encoded by the obese gene, is a multifunctional neuroendocrine peptide
that regulates appetite, bone formation, reproductive function and angiogenesis. The aims of …

Background and aims: Leptin, the product of the ob gene, has been suggested to increase
the risk of colon cancer. However, we have shown that although leptin stimulates epithelial …

Background and aims Obesity increases the risk of colorectal cancer (CRC). Serum leptin
levels are markedly elevated in obese individuals, but the involvement of leptin in CRC …

Although a number of recent studies have reported the involvement of leptin in colorectal
carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously …

Leptin plays a key role regulating food intake, body weight and fat mass. These critical
parameters are associated with an increased risk for digestive and mammary gland cancer …

Background: Leptin is an adipocyte-derived neurohormone, high levels of which are found
in obese individuals. Leptin controls energy expenditure, acting in the brain, and regulates …