Pancreas preservation by cold storage using University of Wisconsin solution was the
mainstay method used for pancreas transplantation during the past 2 decades. Other …

The concept of organ preservation by perfusion dates back to the mid-19th century.
Innovations since then have included temperature regulation, perfusion fluid composition …

Ischemic injury of the human cadaver donor pancreas during cold storage is conceivably the
single most ignored impediment to successful islet cell transplantation. Protecting pancreatic …

Overall, in whole pancreas and islet transplantation, current cold preservation solutions
(University of Wisconsin solution, Celsior, histidine–tryptophan–ketoglutarate) seem to be …

Cold storage may be adequate for preservation before pancreas transplants, but insufficient
when pancreases are processed for islets or when expanded donors are used …

Background. A two-layer (University of Wisconsin solution/perfluorochemical [UW/PFC]) cold-
storage method delivers sufficient oxygen to the pancreas during preservation and restores …

Background. Previous small clinical trials indicate that the two-layer method (TLM) for
pancreas preservation improves islet isolation outcome. However, the effect of TLM has not …

BACKGROUND: Research-grade pancreata preserved by the two-layer method (TLM)
compared to organs stored with University of Wisconsin (UW) solution prior to islet isolation …

Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic
patients. After the successful demonstration of the Edmonton protocol, islet transplantation …

A large number of reports have shown that the two-layer method (TLM), which employs
oxygenated perfluorochemical (PFC) and University of Wisconsin (UW) solution, is superior …