Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

Therapeutic drug monitoring (TDM) is increasingly relevant for an individualized antibiotic
therapy and subsequently a necessary tool to reduce multidrug-resistant pathogens …

Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is
described as a useful tool. However, the minimum inhibitory concentration of piperacillin …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the
unpredictable pharmacokinetic profile of this patient population. Several studies have shown …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Optimization of antibiotic dosing is a treatment intervention that is likely to improve outcomes
in severe infections. The aim of this retrospective study was to describe the therapeutic …