A common nonsense mutation in the repetitive Kringle IV‐2 domain of human apolipoprotein (a) results in a truncated protein and low plasma Lp (a)

W Parson, HG Kraft, H Niederstätter… - Human …, 2004 - Wiley Online Library
LPA, the gene coding for apolipoprotein (a)[apo (a)], is the major determinant of lipoprotein
(a)[Lp (a)] plasma levels, which are associated with risk for coronary heart disease (CHD) …

Apolipoprotein (a) kringle IV repeat number predicts risk for coronary heart disease

HG Kraft, A Lingenhel, S Kochl… - … , and vascular biology, 1996 - Am Heart Assoc
A high plasma concentration of lipoprotein (a)[Lp (a)] has been suggested as a risk factor for
coronary heart disease (CHD), but some recent prospective studies have questioned the …

Sequence microheterogeneity in apolipoprotein (a) gene repeats and the relationship to plasma Lp (a) levels

FP Mancini, V Mooser, R Guerra… - Human molecular …, 1995 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a cholesterol ester-rich atherogenic lipoprotein that is
composed of a particle of low density lipoprotein and a large glycoprotein, apolipoprotein …

The number of identical kringle IV repeats in apolipoprotein (a) affects its processing and secretion by HepG2 cells

C Brunner, EM Lobentanz, A Pethö-Schramm… - Journal of Biological …, 1996 - ASBMB
A variable number of 5.6-kilobase kringle IV repeats in the human apolipoprotein (a)(apo
(a)) gene results in a size polymorphism of the protein and correlates inversely with the …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

The apolipoprotein (a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms

YY Hoek, ME Wittekoek, U Beisiegel… - Human molecular …, 1993 - academic.oup.com
Elevated levels of plasma lipoprotein (a)[Lp (a)] have been correlated with the development
of atherosclerosis in human populations. Apolipoprotein (a)[apo (a); the distinguishing …

Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma

V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …

Molecular basis of congenital lp (a) deficiency: a frequent apo (a)'null'mutation in caucasians

M Ogorelkova, A Gruber… - Human molecular …, 1999 - academic.oup.com
High plasma concentrations of lipoprotein (a)[Lp (a)], a covalent low-density lipoprotein-
apolipoprotein (a)[apo (a)] complex, are associated with coronary heart disease and stroke …

Single nucleotide polymorphisms in exons of the apo (a) kringles IV types 6 to 10 domain affect Lp (a) plasma concentrations and have different patterns in Africans …

M Ogorelkova, HG Kraft, C Ehnholm… - Human molecular …, 2001 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a complex of apolipoprotein (a)[apo (a)] and low-density
lipoprotein which is associated with atherothrombotic disease. Lp (a) plasma levels are …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …