Many cellular stresses activate senescence, a persistent hyporeplicative state characterized
in part by expression of the p16 INK4a cell-cycle inhibitor. Senescent cell production occurs …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It
has been proposed that senescent cells—damaged cells that have lost the ability to divide …

Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal
role in tumor suppression. Cellular senescence may play an important role in tumor …

SnapShot: Cellular Senescence Pathways Page 1 See online version for legends and
references 816 Cell 170, August 10, 2017 © 2017 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cell.2017.07.049 …

Highlights•Persistent DNA damage triggers a senescence-associated secretory
program.•p16 INK4a is a biomarker for senescence and aging but its levels do not predict …

Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …