Novel roles for chemokines and fibroblasts in interstitial fibrosis. Background Regardless of
its involvement in either wound healing or excessive fibrosis, the interstitial fibroblast can …

Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …

Fibrotic disorders of the renal, pulmonary, cardiac, and hepatic systems are associated with
significant morbidity and mortality. Effective therapies to prevent or curtail the advancement …

Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but
the cellular target that mediates its profibrotic actions has not been clearly identified. While in …

The pathogenic mechanisms that lead to chronic kidney disease (CKD) converge on a
common pathway that results in progressive interstitial fibrosis, peritubular capillary loss with …

Tubuloinferstitial fibrosis is a final common pathway for progressive renal injury in
most'inflammatory'and'non-inflammatory'glomerulopathies. Indeed, the level of …

AKI with incomplete epithelial repair is a major contributor to CKD characterized by
tubulointerstitial fibrosis. Injury–induced epithelial secretion of profibrotic factors is …

The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …

Renal fibrosis is the hallmark of virtually all progressive kidney diseases and strongly
correlates with the deterioration of kidney function. The renin-angiotensin-aldosterone …

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM),
leading to destruction of normal kidney architecture and loss of renal function. The activation …