The longstanding focus in chronic kidney disease (CKD) research has been on the
glomerulus, which is sensible because this is where glomerular filtration occurs, and a large …

Proximal tubular cells promote fibrogenesis by TGF-β1–mediated induction of peritubular
myofibroblasts. Background In proteinuric nephropathies with increasingly severe defects of …

Current treatment modalities are not effective in halting the progression of most CKD. Renal
fibrosis is a pathological process common to all CKD and thereby represents an excellent …

Tissue-type plasminogen activator (tPA) is one of the major components in the matrix
proteolytic network whose role in the pathogenesis of renal interstitial fibrosis remains …

Understanding the origin of myofibroblasts in kidney is of great interest because these cells
are responsible for scar formation in fibrotic kidney disease. Recent studies suggest …

Renal fibrosis is the final common pathway for many kidney lesions that lead to chronic
progressive organ failure. The tubulointerstitial space occupies up to 90% of kidney volume …

Elevated expression of the multifunctional cytokine transforming growth factor β1 (TGF-β1) is
causatively linked to kidney fibrosis progression initiated by diabetic, hypertensive …

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-and calcium-dependent
endopeptidase that degrades a broad range of extracellular matrix substrates and additional …

Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present
no antifibrotic therapies exist,–. The origin, functional heterogeneity and regulation of scar …

Tubular injury has a major etiological role in fibrosis. For many years, this relationship has
been dominated by the perception that epithelial cells are transformed into myofibroblasts …