Reversion of β25–35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists

T Maurice, BP Lockhart, TP Su, A Privat - Brain research, 1996 - Elsevier
The effects of d-cycloserine (DCS), a N-methyl-d-aspartate receptor-associated glycine site
agonist, and milacemide (MIL), a glycine prodrug, were examined on learning impairments …

Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction

T Maurice, BP Lockhart, A Privat - Brain research, 1996 - Elsevier
Substantial evidences suggest that the increased cerebral deposition, and neurotoxic action
of the β-amyloid peptide, the major constituent of senile plaques, may represent the …

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents

GE Handelmann, ME Nevins, LL Mueller… - Pharmacology …, 1989 - Elsevier
The N-methyl-D-aspartate receptor complex appears to play an important role in processes
of learning and memory. The presence of a glycine modulatory site at this complex has …

Dynorphin A-(1-13) and (2-13) improve β-amyloid peptide-induced amnesia in mice

M Hiramatsu, K Inoue, T Kameyama - Neuroreport, 2000 - journals.lww.com
The anti-amnesic effects of dynorphins on β-amyloid peptide-(25–35)-induced impairment of
learning and/or memory in mice were investigated using a Y-maze task and a passive …

Cognitive dysfunction induced by sequential injection of amyloid-β and ibotenate into the bilateral hippocampus; protection by memantine and MK-801

S Nakamura, N Murayama, T Noshita… - European journal of …, 2006 - Elsevier
Aggregated 40-residue amyloid-β peptide (β40, 4 μg/μl), and 2 days later, ibotenate (NMDA
receptor agonist, 0.3 μg/0.5 μl), were bilaterally injected into the hippocampus of rats. Five to …

Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor

JF Flood, JE Morley, TH Lanthorn - European journal of pharmacology, 1992 - Elsevier
Glycine has been shown to modulate N-methyl-D-aspartate (NMDA) subclass of acidic
amino acid receptors which have been implicated in learning and memory. We report that d …

Agmatine protects against β-amyloid25-35-induced memory impairments in the rat

DH Bergin, P Liu - Neuroscience, 2010 - Elsevier
Amyloid beta fragment 25-35 (Aβ25-35) is the neurotoxic domain of the full-length Aβ1-42
and causes memory impairments in rodents. Recent research suggests that agmatine …

Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks

J Parada-Turska, WA Turski - Neuropharmacology, 1990 - Elsevier
The role of N-methyl-d-aspartate (NMDA) receptors in memory processes was examined
using a Y-shaped maze and a step-through passive avoidance task in mice. In the Y-maze …

Influence of N-methyl D-aspartate receptor mechanism on WIN55, 212-2-induced amnesia in rat dorsal hippocampus

N Jamali-Raeufy, M Nasehi… - Behavioural …, 2011 - journals.lww.com
In this study, we investigated the effects of both N-methyl D-aspartate (NMDA) and MK-801
on WIN55, 212-2 (WIN)-induced amnesia in rats. Step-through inhibitory avoidance of …

Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism

T Maurice, TP Su, A Privat - Neuroscience, 1998 - Elsevier
The sigma1 (σ1) receptor agonists exert potent anti-amnesic effects, as they apparently
block the learning impairments either induced by the muscarinic receptor antagonist …