Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets
J Royea, E Hamel - Geroscience, 2020 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature. Yet,
despite being the most common form of dementia in the elderly, AD's primary cause remains …
despite being the most common form of dementia in the elderly, AD's primary cause remains …
[HTML][HTML] Therapeutic Implications of Renin–Angiotensin System Modulators in Alzheimer's Dementia
The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its
traditional cardiovascular role due to emerging data indicating its potential involvement in …
traditional cardiovascular role due to emerging data indicating its potential involvement in …
The brain RAS and Alzheimer's disease
JW Wright, JW Harding - Experimental neurology, 2010 - Elsevier
Alzheimer's disease (AD) has become a major world-wide health problem with ever rising
costs associated with the treatment and care of afflicted individuals. As life expectancy has …
costs associated with the treatment and care of afflicted individuals. As life expectancy has …
Roles of brain angiotensin II in cognitive function and dementia
M Mogi, J Iwanami, M Horiuchi - International Journal of …, 2012 - Wiley Online Library
The brain renin‐angiotensin system (RAS) has been highlighted as having a pathological
role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia …
role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia …
Contributions by the brain renin-angiotensin system to memory, cognition, and Alzheimer's disease
JW Wright, JW Harding - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
neuron losses in memory-associated brain structures that rob patients of their dignity and …
neuron losses in memory-associated brain structures that rob patients of their dignity and …
[HTML][HTML] Circulating angiotensin-(1–7) Is reduced in Alzheimer's disease patients and correlates with white matter abnormalities: results from a pilot study
VT Ribeiro, TM Cordeiro, RS Filha, LG Perez… - Frontiers in …, 2021 - frontiersin.org
Introduction Alzheimer's disease (AD) is the leading cause of dementia worldwide. Despite
the extensive research, its pathophysiology remains largely unelucidated. Currently, more …
the extensive research, its pathophysiology remains largely unelucidated. Currently, more …
Renin-angiotensin system alterations in the human Alzheimer's disease brain
S Ismael, G Mirzahosseini, HA Ahmed… - Journal of …, 2021 - content.iospress.com
Background: Understanding Alzheimer's disease (AD) in terms of its various
pathophysiological pathways is essential to unravel the complex nature of the disease …
pathophysiological pathways is essential to unravel the complex nature of the disease …
[HTML][HTML] The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment?
PG Kehoe - Journal of Alzheimer's Disease, 2018 - content.iospress.com
There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …
Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer's disease
J Royea, L Zhang, XK Tong, E Hamel - Journal of Neuroscience, 2017 - Soc Neuroscience
The use of angiotensin receptor blockers (ARBs) correlates with reduced onset and
progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as …
progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as …
Evidence to consider angiotensin II receptor blockers for the treatment of early Alzheimer's disease
JM Saavedra - Cellular and molecular neurobiology, 2016 - Springer
Alzheimer's disease is the most frequent type of dementia and diagnosed late in the
progression of the illness when irreversible brain tissue loss has already occurred. For this …
progression of the illness when irreversible brain tissue loss has already occurred. For this …