Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets

J Royea, E Hamel - Geroscience, 2020 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature. Yet,
despite being the most common form of dementia in the elderly, AD's primary cause remains …

[HTML][HTML] Therapeutic Implications of Renin–Angiotensin System Modulators in Alzheimer's Dementia

DC Ababei, V Bild, I Macadan, A Vasincu, RN Rusu… - Pharmaceutics, 2023 - mdpi.com
The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its
traditional cardiovascular role due to emerging data indicating its potential involvement in …

The brain RAS and Alzheimer's disease

JW Wright, JW Harding - Experimental neurology, 2010 - Elsevier
Alzheimer's disease (AD) has become a major world-wide health problem with ever rising
costs associated with the treatment and care of afflicted individuals. As life expectancy has …

Roles of brain angiotensin II in cognitive function and dementia

M Mogi, J Iwanami, M Horiuchi - International Journal of …, 2012 - Wiley Online Library
The brain renin‐angiotensin system (RAS) has been highlighted as having a pathological
role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia …

Contributions by the brain renin-angiotensin system to memory, cognition, and Alzheimer's disease

JW Wright, JW Harding - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
neuron losses in memory-associated brain structures that rob patients of their dignity and …

[HTML][HTML] Circulating angiotensin-(1–7) Is reduced in Alzheimer's disease patients and correlates with white matter abnormalities: results from a pilot study

VT Ribeiro, TM Cordeiro, RS Filha, LG Perez… - Frontiers in …, 2021 - frontiersin.org
Introduction Alzheimer's disease (AD) is the leading cause of dementia worldwide. Despite
the extensive research, its pathophysiology remains largely unelucidated. Currently, more …

Renin-angiotensin system alterations in the human Alzheimer's disease brain

S Ismael, G Mirzahosseini, HA Ahmed… - Journal of …, 2021 - content.iospress.com
Background: Understanding Alzheimer's disease (AD) in terms of its various
pathophysiological pathways is essential to unravel the complex nature of the disease …

[HTML][HTML] The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment?

PG Kehoe - Journal of Alzheimer's Disease, 2018 - content.iospress.com
There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …

Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer's disease

J Royea, L Zhang, XK Tong, E Hamel - Journal of Neuroscience, 2017 - Soc Neuroscience
The use of angiotensin receptor blockers (ARBs) correlates with reduced onset and
progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as …

Evidence to consider angiotensin II receptor blockers for the treatment of early Alzheimer's disease

JM Saavedra - Cellular and molecular neurobiology, 2016 - Springer
Alzheimer's disease is the most frequent type of dementia and diagnosed late in the
progression of the illness when irreversible brain tissue loss has already occurred. For this …