Angiotensin-(1-7) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer's disease

T Jiang, YD Zhang, JS Zhou, XC Zhu, YY Tian… - Molecular …, 2016 - Springer
As a recently identified bioactive peptide of brain renin-angiotensin system (RAS),
angiotensin-(1-7)[Ang-(1-7)] along with its metabolic enzyme angiotensin-converting …

[HTML][HTML] Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease

J Royea, P Martinot, E Hamel - Neurobiology of Disease, 2020 - Elsevier
Angiotensin II type 1 receptor antagonists like losartan have been found to lower the
incidence and progression to Alzheimer's disease (AD), as well as rescue cognitive and …

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

CE Evans, JS Miners, G Piva, CL Willis, DM Heard… - Acta …, 2020 - Springer
Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

Effect of angiotensin II type 2 receptor on stroke, cognitive impairment and neurodegenerative diseases

M Mogi, M Horiuchi - Geriatrics & gerontology international, 2013 - Wiley Online Library
Here, we briefly review the role of the renin–angiotensin system (RAS) in cognitive
impairment and neurodegenerative disease, mainly discussing our experimental studies on …

Angiotensin II, a neuropeptide at the frontier between endocrinology and neuroscience: is there a link between the angiotensin II type 2 receptor and Alzheimer's …

N Gallo-Payet, MO Guimond, L Bilodeau… - Frontiers in …, 2011 - frontiersin.org
Amyloid-β peptide deposition, abnormal hyperphosphorylation of tau, as well as
inflammation and vascular damage, are associated with the development of Alzheimer's …

Brain renin–angiotensin system at the intersect of physical and cognitive frailty

C Cosarderelioglu, LS Nidadavolu… - Frontiers in …, 2020 - frontiersin.org
The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model

B Ongali, N Nicolakakis, XK Tong, T Aboulkassim… - Neurobiology of …, 2014 - Elsevier
Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may
protect from Alzheimer's disease (AD). We studied the ability of the AT1 receptor antagonist …

Rationale and design of the mechanistic potential of antihypertensives in preclinical Alzheimer's (HEART) trial

W Wharton, FC Goldstein, MG Tansey… - Journal of …, 2018 - content.iospress.com
Research indicates that certain antihypertensive medications alter Alzheimer's disease (AD)
biomarkers in Caucasians. The renin angiotensin system (RAS) regulates blood pressure …

Brain renin–angiotensin system as novel and potential therapeutic target for Alzheimer's disease

R Loera-Valencia, F Eroli, S Garcia-Ptacek… - International journal of …, 2021 - mdpi.com
The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the
pathophysiology of cognition. While the brain RAS has been studied before in the context of …

Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease

L Danielyan, R Klein, LR Hanson, M Buadze… - Rejuvenation …, 2010 - liebertpub.com
The local renin–angiotensin system (RAS) in the brain is a multitasking system controlling a
plethora of essential functions such as neurogenic hypertension, baroreflexes, and …