Excessive allostatic load as a consequence of deregulated brain inflammation participates
in the development and progression of multiple brain diseases, including but not limited to …

The renin-angiotensin system (RAS) is a major circulative system engaged in homeostasis
modulation. Angiotensin II (Ang II) serves as its main effector hormone upon binding to its …

Renin angiotensin system (RAS) is an endocrine system widely known for its physiological
roles in electrolyte homeostasis, body fluid volume regulation and cardiovascular control in …

Because growing evidence suggests that angiotensin II receptor blockers (ARBs) effectively
inhibit oxidative stress, amyloid beta protein (Aβ) metabolism, and tau phosphorylation in …

Background Angiotensin binds to at least two different receptors, termed AT1 and AT2.
Animal studies suggest that the AT2 receptor is neuroprotective. ACE inhibitors, such as …

Hypertension is a major risk factor for the pathogenesis of vascular dementia and
Alzheimer's disease. Chronic activation of the renin-angiotensin system (RAS) contributes …

The reported primary dementia-protective benefits of angiotensin II type 1 receptor (AT1R)
blockers (ARB) are believed, at least in part, to arise from systemic effects on blood …

Work on the brain renin–angiotensin system has been explored by various researchers and
has led to elucidation of its basic physiologies and behavior, including its role in …

The pathology of Alzheimer's disease (AD) features amyloid β peptide deposition,
intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood …

A brain renin angiotensin system (RAS) and its role in cardiovascular control and fluid
homeostasis was at first controversial. This was because a circulating kidney-derived renin …