The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Background The antihypertensive angiotensin receptor blockers (ARBs) and angiotensin-
converting enzyme inhibitors (ACE-Is) have similar indications and mechanisms of action …

Background: The functioning of the central nervous system is complex and it implies tight
and coordinated interactions among multiple components. Neurotransmitters systems …

Background With the aging population, the prevalence and incidence of cerebrovascular
disease will continue to rise, as well as the number of individuals with vascular cognitive …

Stroke is the 2nd leading cause of death worldwide and the leading cause of physical
disability and cognitive issues. Although we have made progress in certain aspects of stroke …

The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte
homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS …

Background: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and
Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and …

Increased generation of reactive oxygen species (ROS) is a significant pathological feature
in the brains of patients with Alzheimer's disease (AD). Experimental evidence indicates that …

Observations in autopsied brain tissue indicate that overactivation of the classical renin-
angiotensin system (cRAS) and underactivity within regulatory RAS pathways (rRAS) are …

Objectives To assess the effect of modulation of the renin‐angiotensin system (RAS) on
conversion to Alzheimer's disease (AD) and cognitive decline in people with mild cognitive …