Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE

M Chen, M Nagase, T Fujita, S Narumiya… - Biochemical and …, 2001 - Elsevier
Diabetes mellitus accelerating atherosclerosis was associated with the enhanced
glycoxidative modification of lipoproteins. LOX-1, the endothelial oxidized LDL receptor …

Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction

M Tatsuguchi, M Furutani, J Hinagata, T Tanaka… - Biochemical and …, 2003 - Elsevier
Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to
play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a …

CRP is a novel ligand for the oxidized LDL receptor LOX-1

HH Shih, S Zhang, W Cao, A Hahn… - American Journal …, 2009 - journals.physiology.org
C-reactive protein (CRP) is a risk factor for cardiovascular events and functions to amplify
vascular inflammation through promoting endothelial dysfunction. Lectin-like oxidized low …

Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability—analysis in hypercholesterolemic rabbits

S Ishino, T Mukai, N Kume, D Asano, M Ogawa, Y Kuge… - Atherosclerosis, 2007 - Elsevier
Lectin-like oxidized LDL receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL (Ox-
LDL), has been implicated in vascular cell dysfunction related to atherosclerotic plaque …

Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes

E Iwai-Kanai, K Hasegawa, T Sawamura, M Fujita… - Circulation, 2001 - Am Heart Assoc
Background—Lectin-like oxidized LDL receptor-1 (LOX-1) was originally identified as a
receptor expressed predominantly in endothelial cells. LOX-1 can also be expressed in …

Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture

N Kume, T Kita - Circulation research, 2004 - Am Heart Assoc
Atherosclerotic plaque rupture followed by thrombus formation is a key event in the onset of
acute coronary syndrome. 1 Apoptotic death of smooth muscle cells in the fibrous cap of the …

Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation

DY Li, HJ Chen, JL Mehta - Cardiovascular Research, 2001 - academic.oup.com
Abstract Objectives: LOX-1, a lectin-like receptor on endothelial cells, facilitates the uptake of
oxidized-LDL. Expression of LOX-1 is involved in the pathobiological effects of oxidized-LDL …

Intracellular signaling of LOX-1 in endothelial cell apoptosis

D Li, JL Mehta - Circulation Research, 2009 - Am Heart Assoc
Rupture of the cap covering the atherosclerotic plaque is thought to lead to platelet
deposition and formation of an occlusive thrombus resulting in cessation of blood flow …

LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation

D Li, V Williams, L Liu, H Chen… - American Journal …, 2002 - journals.physiology.org
A recently identified lectin-like oxidized low-density lipoprotein receptor (LOX-1) mediates
endothelial cell injury and facilitates inflammatory cell adhesion. We studied the role of LOX …

Oxidized LDL, LOX-1 and atherosclerosis

S Mitra, T Goyal, JL Mehta - Cardiovascular drugs and therapy, 2011 - Springer
An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor
for genesis of atherosclerosis. Ox-LDL plays a more important role in the genesis and …