[HTML][HTML] Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR …

Y Bai, X Liu, L Zheng, S Wang, J Zhang, S Xiong… - Neoplasia, 2023 - Elsevier
Common sensitizing mutations in epidermal growth factor receptor (cEGFR), including exon
19 deletions (19-Del) and exon 21 L858R substitution, are associated with high sensitivity to …

[HTML][HTML] Concomitant genetic alterations are associated with worse clinical outcome in EGFR mutant NSCLC patients treated with tyrosine kinase inhibitors

SC Chang, YC Lai, CY Chang, LK Huang, SJ Chen… - Translational …, 2019 - Elsevier
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are recommended
first-line therapy for advanced non-small cell lung cancer (NSCLC) with sensitizing EGFR …

The Predictive Values of Advanced Non-Small Cell Lung Cancer Patients Harboring Uncommon EGFR Mutations—The Mutation Patterns, Use of Different …

J Tan, C Hu, P Deng, R Wan, L Cao, M Li… - Frontiers in …, 2021 - frontiersin.org
Introduction Epidermal growth factor receptor (EGFR) 19del and L858R mutation are known
as “common mutations” in non-small cell lung cancer (NSCLC) and predict sensitivities to …

Heterogeneous responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with uncommon EGFR mutations: new insights and …

A Russo, T Franchina, G Ricciardi, A Battaglia… - International Journal of …, 2019 - mdpi.com
Uncommon Epidermal Growth Factor Receptor (EGFR) mutations represent a distinct and
highly heterogeneous subgroup of Non-Small Cell Lung Cancers (NSCLCs), that accounts …

Treatment strategies for non-small cell lung cancer harboring common and uncommon EGFR mutations: drug sensitivity based on exon classification, and structure …

R Kitadai, Y Okuma - Cancers, 2022 - mdpi.com
Simple Summary The advent of epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitors (EGFR-TKIs) has led to a dramatic improvement in the prognosis of patients …

Comprehensive characterization and clinical impact of concomitant genomic alterations in EGFR-mutant NSCLCs treated with EGFR kinase inhibitors

Y Cheng, L Ma, Y Liu, J Zhu, Y Xin, X Liu, Y Wang… - Lung cancer, 2020 - Elsevier
Objectives Although the majority of epidermal growth factor receptor (EGFR)-mutant non-
small cell lung cancer (NSCLC) patients respond to EGFR tyrosine kinase inhibitors (TKIs) …

[HTML][HTML] Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes

T John, A Taylor, H Wang, C Eichinger, C Freeman… - Cancer …, 2022 - Elsevier
Mutations in exons 18–21 of the epidermal growth factor receptor gene (EGFR) can confer
sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small-cell …

Concurrent genetic alterations and other biomarkers predict treatment efficacy of EGFR-TKIs in EGFR-mutant non-small cell lung cancer: a review

Y Guo, J Song, Y Wang, L Huang, L Sun, J Zhao… - Frontiers in …, 2020 - frontiersin.org
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) greatly improve the
survival and quality of life of non-small cell lung cancer (NSCLC) patients with EGFR …

Genetic mutation profiling reveals biomarkers for targeted therapy efficacy and prognosis in non-small cell lung cancer

H Bai, Y Zhou, W Liu, W Xu, L Cheng, Y Huo, H Ji… - Heliyon, 2024 - cell.com
Introduction The genetic heterogeneity of non-small cell lung cancer (NSCLC) with
epidermal growth factor receptor (EGFR) mutations may affect clinical responses and …

Uncommon frame-shift exon 19 EGFR mutations are sensitive to EGFR tyrosine kinase inhibitors in non-small cell lung carcinoma

G Improta, A Zupa, MI Natalicchio, L Sisinni… - Medical Oncology, 2018 - Springer
Exons 19–21 EGFR activating mutations are predictive biomarkers of response to EGFR
tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). However …