Proteins, nucleic acids, and lipids can undergo various forms of oxidative modification. In
numerous instances, these modifications result in irreversible loss of function. The age …

Rapid developments in free radical biology and molecular technology have permitted
exploration of the free radical theory of aging. Oxidative stress has also been implicated in …

Although the free radical theory of aging was proposed several decades ago the
involvement of radicals in the aging process remains obscure. Considerable progress has …

Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Aging is a complex process that affects every major system at the molecular, cellular and
organ levels. Although the exact cause of aging is unknown, there is significant evidence …

Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Aging processes are time-dependent, deteriorative functional changes. These functional
changes lead to a progressive loss of the organism's ability to withstand both internal and …

Organisms produce reactive oxygen species (ROS) throughout their lives. The activities of a
number of key antioxidant enzymes, such as catalase, superoxide dismutase and …