Fascinating biological questions cluster around the phenomenon of development and aging.
Does every species age in the same way as the human? Is there a fundamental process of …

Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

The existence of free radicals, as chemical entities, was inferred 100 years ago but not
universally accepted for some 30–40 years. The existence and importance of free radicals in …

The field of aging research has progressed significantly over the past decades. Exogenously
and endogenously inflicted molecular damage ranging from genotoxic to organellar damage …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Arlan Richardson received his PhD in chemistry from Oklahoma State University and did his
postdoctoral training at the University of Minnesota. In 1971, he joined the faculty at Illinois …

Oxidative stress due to excessive amounts of reactive oxygen species (ROS) and reactive
nitrogen species (RNS) plays a leading role in damages to macromolecules and, as such, it …

Cellular senescence, a cell state characterized by a generally irreversible cell cycle arrest, is
implicated in various physiological processes and a wide range of age-related pathologies …

Significance: The oxidative stress theory of aging has been the most widely accepted theory
of aging providing insights into why we age and die for over 50 years, despite mounting …

The hypothesis that the rate of oxygen consumption and the ensuing accrual of molecular
oxidative damage constitute a fundamental mechanism governing the rate of aging is …