Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies

YA Lee, SL Friedman - Journal of Internal Medicine, 2022 - Wiley Online Library
Non‐alcoholic fatty liver disease is comprised of either simple steatosis (non‐alcoholic fatty
liver) or a more advanced inflammatory and fibrogenic stage (non‐alcoholic steatohepatitis …

Current and potential therapies targeting inflammation in NASH

S Albhaisi, M Noureddin - Frontiers in endocrinology, 2021 - frontiersin.org
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease
(NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and …

Triggering and resolution of inflammation in NASH

S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

F Tacke, T Puengel, R Loomba, SL Friedman - Journal of Hepatology, 2023 - Elsevier
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …

Nonalcoholic steatohepatitis (NASH) and hepatic fibrosis: emerging therapies

J Wattacheril, D Issa, A Sanyal - Annual review of pharmacology …, 2018 - annualreviews.org
Nonalcoholic fatty liver disease remains a major cause of liver-related morbidity and
mortality worldwide. It is a complex disease associated with obesity, diabetes, and …

Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Targeting cell death and sterile inflammation loop for the treatment of nonalcoholic steatohepatitis

A Wree, WZ Mehal, AE Feldstein - Seminars in liver disease, 2016 - thieme-connect.com
Nonalcoholic fatty liver disease represents a wide spectrum of conditions and is currently the
most common form of chronic liver disease affecting both adults and children in the United …

[HTML][HTML] New targets for NAFLD

L Parlati, M Régnier, H Guillou, C Postic - JHEP Reports, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …