The effect of low molecular weight heparin on survival in patients with advanced malignancy

CPW Klerk, SM Smorenburg, HM Otten… - Journal of clinical …, 2005 - ascopubs.org
Purpose Studies in cancer patients with venous thromboembolism suggested that low
molecular weight heparin may prolong survival. In a double-blind study, we evaluated the …

[PDF][PDF] Randomized trial of the effect of the low molecular weight heparin nadroparin on survival in patients with cancer

FF van Doormaal, M Di Nisio, HM Otten, DJ Richel… - J Clin …, 2011 - researchgate.net
Purpose Earlier studies showed that low molecular weight heparin significantly prolongs the
survival of a wide variety of patients with cancer without venous thromboembolism. This …

Low-molecular-weight heparin in patients with advanced cancer: a phase 3 clinical trial

K Sideras, PL Schaefer, SH Okuno, JA Sloan… - Mayo Clinic …, 2006 - Elsevier
OBJECTIVE To prospectively assess whether low-molecular-weight heparin (LMWH)
provides a survival benefit in patients with advanced cancer. PATIENTS AND METHODS …

[HTML][HTML] The effect of low‐molecular‐weight heparin on cancer survival. A systematic review and meta‐analysis of randomized trials

A Lazo‐Langner, GD Goss, JN Spaans… - Journal of Thrombosis …, 2007 - Elsevier
Background: Low‐molecular‐weight heparins (LMWH) have an antitumor effect in vitro and
in experimental animal models of malignancy. Retrospective data suggest that it might …

Low-molecular-weight heparin and cancer

LR Zacharski, DL Ornstein… - Seminars in thrombosis …, 2000 - thieme-connect.com
Heparin is a familiar anticoagulant drug with properties that may impede tumor growth; it
modifies properties of cells that contribute to malignant dissemination such as angiogenesis …

[HTML][HTML] The effect of low molecular weight heparin on survival in cancer patients: an updated systematic review and meta‐analysis of randomized trials

D Sanford, A Naidu, N Alizadeh… - Journal of Thrombosis and …, 2014 - Elsevier
Background Tumors may exploit the coagulation system to enhance the survival and
dissemination of cancer cells. Some studies have suggested that heparin and low molecular …

Do heparins do more than just treat thrombosis? The influence of heparins on cancer spread

RJK Hettiarachchi, SM Smorenburg… - Thrombosis and …, 1999 - thieme-connect.com
The influence of unfractionated heparin (UFH) and other anticoagulants on the spread of
cancer has been reported since the early 1960s. 1 However, clinical studies investigating …

[PDF][PDF] Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism

AYY Lee, FR Rickles, JA Julian, M Gent… - Journal of Clinical …, 2005 - Citeseer
Purpose Experimental studies and indirect clinical evidence suggest that low molecular
weight heparins may have antineoplastic effects. We investigated the influence of a low …

Randomized phase III trial of standard therapy plus low molecular weight heparin in patients with lung cancer: FRAGMATIC trial

F Macbeth, S Noble, J Evans… - Journal of Clinical …, 2016 - eprints.whiterose.ac.uk
Purpose Venous thromboembolism (VTE) is common in cancer patients. Evidence has
suggested that low molecular weight heparin (LMWH) might improve survival in patients with …

Anti-cancer properties of low-molecular-weight heparin: preclinical evidence

SA Mousa, LJ Petersen - Thrombosis and haemostasis, 2009 - thieme-connect.com
Malignant conditions are frequently associated with a hypercoaguable state, with recurrent
thrombosis due to the impact of cancer cells and chemotherapy or radiotherapy on the …