Introduction: Several mouse models with diverse disease etiologies are used in preclinical
research for chronic kidney disease (CKD). Here, we performed a head-to-head comparison …

Background Current uncertainties about the similarity between human diseases and their
experimental models are hampering the development of new therapies. This is especially …

The current understanding of molecular mechanisms driving diabetic kidney disease (DKD)
is limited, partly due to the complex structure of the kidney. To identify genes and signalling …

Background: Translational rodent models are essential to identify more efficacious treatment
options for patients with chronic kidney disease (CKD). However, most preclinical CKD …

Introduction To develop effective therapies and identify novel early biomarkers for chronic
kidney disease, an understanding of the molecular mechanisms orchestrating it is essential …

Background Mouse models have been widely used to understand kidney disease
pathomechanisms and play an important role in drug discovery. However, these models …

Although chronic kidney disease (CKD) is common, only a fraction of CKD patients progress
to end-stage renal disease. Molecular predictors to stratify CKD populations according to …

Background: C57BL/6 mice are commonly used murine models with the desired genetic
background for modification in different research settings. So far, there is still a lack of …

Despite advances in the treatment of diabetic nephropathy (DN), currently available
therapies have not prevented the epidemic of progressive chronic kidney disease (CKD) …

To develop efficient therapies and identify novel early biomarkers for chronic kidney disease
an understanding of the molecular mechanisms orchestrating it is essential. We here set out …