Diffusion imaging and bound pool fraction (BPF) mapping are two quantitative magnetic
resonance imaging techniques that measure microstructural features of the white matter of …

The image contrast in magnetic resonance imaging (MRI) is highly sensitive to several
mechanisms that are modulated by the properties of the tissue environment. The degree and …

Estimating intra-and extra-axonal microstructure parameters, such as volume fractions and
diffusivities, has been one of the major efforts in brain microstructure imaging with MRI. The …

Understanding diffusion-weighted MR signal in brain white matter (WM) has been a long-
sought-after goal. Modern research pursues this goal by focusing on the biological …

Brownian motion of water molecules provides an essential length scale, the diffusion length,
commensurate with cell dimensions in biological tissues. Measuring the diffusion coefficient …

Biophysical modeling lies at the core of evaluating tissue cellular structure using diffusion-
weighted MRI, albeit with shortcomings. The challenges lie not only in the complexity of the …

We compare T2-relaxation and diffusion tensor data from normal human brain. The
relationships between myelin-water fraction (MWF) and various diffusion tensor measures …

One of the major goals of the NIH Blueprint Human Connectome Project was to map and
quantify the white matter connections in the brain using diffusion tractography. Given the …

The diffusion time dependence of the brain water diffusion tensor provides information
regarding diffusion restriction and hindrance but has received little attention, primarily due to …

The complex structural organization of the white matter of the brain can be depicted in vivo
in great detail with advanced diffusion magnetic resonance (MR) imaging schemes …