Background: Cartilage oligomeric matrix protein (COMP) is the fifth member of the
thrombospondin family of extracellular, calcium‐binding proteins. It was initially isolated and …

Study Design. Whole rat intervertebral disc (IVD), as well as the anulus fibrosus (AF) and the
nucleus pulposus (NP) were studied using immunoblot, immunohistochemistry, and reverse …

In humans, mutations in cartilage oligomeric matrix protein (COMP) cause autosomal
dominantly inherited skeletal dysplasias. We have generated transgenic mouse lines to …

Objective: Cartilage oligomeric matrix protein (COMP), primarily found in cartilage, is thought
to be an important regulator of assembly and maintenance of the fibrillar collagen I and II …

Cartilage oligomeric matrix protein (COMP) is a large, multifunctional extracellular protein
that, when mutated, is retained in the rough endoplasmic reticulum (ER). This retention …

Objective To investigate the suitability of cartilage oligomeric matrix protein (COMP) as a
marker for articular cartilage degeneration in a transgenic mouse model of osteoarthritis …

Mouse cartilage oligomeric matrix protein cDNA was cloned and sequenced by a reverse
transcription‐polymerase chain reaction. The open reading frame encoded a product of 755 …

Objective Cartilage oligomeric matrix protein (COMP) is a cartilage matrix macromolecule.
The protein is detectable in serum and has been investigated as a biomarker of …

ABSTRACT A case–control study was conducted to estimate the association of cartilage
oligomeric matrix protein (COMP) with knee osteoarthritis (OA) and to examine the potential …

Objective To investigate the effect of overexpression of cartilage oligomeric matrix protein
(COMP) on bone morphogenetic protein‐2 (BMP‐2) induced osteogenic and chondrogenic …