Alterations in the Wnt signaling pathway including those impacting hepatic stellate cells
(HSCs) have been implicated in liver fibrosis. In the current study, we first examined the …

Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …

The Wnt system is highly complex and is comprised of canonical and non-canonical
pathways leading to the activation of gene expression. Our aim was to examine changes in …

BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …

It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …

AIM: To identify differentially expressed genes in quiescent and activated hepatic stellate
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …

Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced
in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we …

Liver‐specific β‐catenin knockout (β‐Catenin‐LKO) mice have revealed an essential role of
β‐catenin in metabolic zonation where it regulates pericentral gene expression and in …