Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

The protective blood–brain barrier has a major role in ensuring normal brain function by
severely limiting and tightly controlling the ingress of substances into the brain from the …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that controls the
mass transfer between blood and brain, severely limits brain penetration of systemically …

Brain metastases encompass nearly 80% of all intracranial tumors. A late stage diagnosis
confers a poor prognosis, with patients typically surviving less than 2 years. Poor survival …

Effective treatments for brain tumors remain one of the most urgent and unmet needs in
modern oncology. This is due not only to the presence of the neurovascular unit/blood–brain …

Brain tumors are characterized by very high mortality and, despite the continuous research
on new pharmacological interventions, little therapeutic progress has been made. One of the …

Resection of brain tumors is followed by chemotherapy and radiation to ablate remaining
malignant cell populations. Targeting these populations stands to reduce tumor recurrence …

The blood–brain barrier (BBB) is of pivotal importance to maintain homeostasis of the CNS,
as it closely regulates the composition of the interstitial fluid in the brain. Unfortunately …

A basic understanding of the blood–brain barrier (BBB) is essential for the novel
advancements in targeting drugs specific to the brain. Neoplasm compromising the internal …