Epigenetic changes in the acute kidney injury-to-chronic kidney disease transition

M Nangaku, Y Hirakawa, I Mimura, R Inagi, T Tanaka - Nephron, 2017 - karger.com
Previously acute kidney injury (AKI) had been believed to be a transient event, and recovery
from AKI had been thought to lead to no consequences. However, recent epidemiological …

Epigenetic modification drives acute kidney injury-to-chronic kidney disease progression

Z Li, N Li - Nephron, 2021 - karger.com
Acute kidney injury (AKI) is a common clinical critical disease. Due to its high morbidity,
increasing risk of complications, high mortality rate, and high medical costs, it has become a …

Hypoxia as a key player in the AKI-to-CKD transition

S Tanaka, T Tanaka… - American Journal of …, 2014 - journals.physiology.org
Recent clinical and animal studies have shown that acute kidney injury (AKI), even if
followed by complete recovery of renal function, can eventually result in chronic kidney …

[HTML][HTML] Therapies targeting epigenetic alterations in acute kidney injury-to-chronic kidney disease transition

F Tanemoto, I Mimura - Pharmaceuticals, 2022 - mdpi.com
Acute kidney injury (AKI) was previously thought to be a merely transient event; however,
recent epidemiological evidence supports the existence of a causal relationship between …

Comparison of acute kidney injury of different etiology reveals in-common mechanisms of tissue damage

M Hultström, M Becirovic-Agic… - Physiological …, 2018 - journals.physiology.org
Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate and urine
production caused by a number of different diseases. It is associated with renal tissue …

[HTML][HTML] AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

L He, Q Wei, J Liu, M Yi, Y Liu, H Liu, L Sun, Y Peng… - Kidney international, 2017 - Elsevier
Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although
AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very …

Acute kidney injury to chronic kidney disease transition

M Fiorentino, G Grandaliano, L Gesualdo… - Acute Kidney Injury …, 2018 - karger.com
Background: Acute kidney injury (AKI), even if followed by renal recovery, is a risk factor for
the future development of chronic kidney disease (CKD) and end-stage renal disease …

Identifying common molecular mechanisms in experimental and human acute kidney injury

LMS Gerhardt, AP McMahon - Seminars in nephrology, 2022 - Elsevier
Acute kidney injury (AKI) is a highly prevalent, heterogeneous syndrome, associated with
increased short-and long-term mortality. A multitude of different factors cause AKI including …

[HTML][HTML] Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury

R Sharifian, DM Okamura, O Denisenko, RA Zager… - Scientific reports, 2018 - nature.com
Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late
phases of a pathologic continuum of interconnected disease states. Although changes in …

Epigenetic changes mediating transition to chronic kidney disease: Hypoxic memory.

T Tanaka - Acta Physiologica, 2018 - search.ebscohost.com
An editorial is presented, in which the author discusses epigenetic changes mediating
transition to chronic kidney disease. It mentions an increase in risk for chronic kidney …