Spatial modeling of cell signaling networks
The shape of a cell, the sizes of subcellular compartments, and the spatial distribution of
molecules within the cytoplasm can all control how molecules interact to produce a cellular …
molecules within the cytoplasm can all control how molecules interact to produce a cellular …
Quantitative understanding of cell signaling: the importance of membrane organization
K Radhakrishnan, A Halasz, D Vlachos… - Current opinion in …, 2010 - Elsevier
Systems biology modeling of signal transduction pathways traditionally employs ordinary
differential equations, deterministic models based on the assumptions of spatial …
differential equations, deterministic models based on the assumptions of spatial …
Modeling, signaling and cytoskeleton dynamics: integrated modeling‐experimental frameworks in cell migration
Cell migration is a complex and multistep process involved in homeostasis maintenance,
morphogenesis, and disease development, such as cancer metastasis. Modeling cell …
morphogenesis, and disease development, such as cancer metastasis. Modeling cell …
Modelling spatio-temporal interactions within the cell
P Rangamani, R Iyengar - Journal of biosciences, 2007 - Springer
Biological phenomena at the cellular level can be represented by various types of
mathematical formulations. Such representations allow us to carry out numerical simulations …
mathematical formulations. Such representations allow us to carry out numerical simulations …
Modelling cellular signalling systems
P Rangamani, R Iyengar - Essays in Biochemistry, 2008 - portlandpress.com
Cell signalling pathways and networks are complex and often non-linear. Signalling
pathways can be represented as systems of biochemical reactions that can be modelled …
pathways can be represented as systems of biochemical reactions that can be modelled …
Computational cell biology: spatiotemporal simulation of cellular events
BM Slepchenko, JC Schaff, JH Carson… - Annual review of …, 2002 - annualreviews.org
▪ Abstract The field of computational cell biology has emerged within the past 5 years
because of the need to apply disciplined computational approaches to build and test …
because of the need to apply disciplined computational approaches to build and test …
Approaches and tools for modeling signaling pathways and calcium dynamics in neurons
KT Blackwell - Journal of neuroscience methods, 2013 - Elsevier
Signaling pathways are cascades of intracellular biochemical reactions that are activated by
transmembrane receptors, and ultimately lead to transcription in the nucleus. In neurons …
transmembrane receptors, and ultimately lead to transcription in the nucleus. In neurons …
Quantitative cell biology with the Virtual Cell
Cell biological processes are controlled by an interacting set of biochemical and
electrophysiological events that are distributed within complex cellular structures …
electrophysiological events that are distributed within complex cellular structures …
The Virtual Cell: a software environment for computational cell biology
LM Loew, JC Schaff - TRENDS in Biotechnology, 2001 - cell.com
The newly emerging field of computational cell biology requires software tools that address
the needs of a broad community of scientists. Cell biological processes are controlled by an …
the needs of a broad community of scientists. Cell biological processes are controlled by an …
Models of cell signaling pathways
US Bhalla - Current opinion in genetics & development, 2004 - Elsevier
Cellular signaling circuits handle an enormous range of computations. Beyond the
housekeeping, replicating and other functions of individual cells, signaling circuits must …
housekeeping, replicating and other functions of individual cells, signaling circuits must …