The shape of a cell, the sizes of subcellular compartments, and the spatial distribution of
molecules within the cytoplasm can all control how molecules interact to produce a cellular …

Systems biology modeling of signal transduction pathways traditionally employs ordinary
differential equations, deterministic models based on the assumptions of spatial …

Cell migration is a complex and multistep process involved in homeostasis maintenance,
morphogenesis, and disease development, such as cancer metastasis. Modeling cell …

Biological phenomena at the cellular level can be represented by various types of
mathematical formulations. Such representations allow us to carry out numerical simulations …

Cell signalling pathways and networks are complex and often non-linear. Signalling
pathways can be represented as systems of biochemical reactions that can be modelled …

▪ Abstract The field of computational cell biology has emerged within the past 5 years
because of the need to apply disciplined computational approaches to build and test …

Signaling pathways are cascades of intracellular biochemical reactions that are activated by
transmembrane receptors, and ultimately lead to transcription in the nucleus. In neurons …

Cell biological processes are controlled by an interacting set of biochemical and
electrophysiological events that are distributed within complex cellular structures …

The newly emerging field of computational cell biology requires software tools that address
the needs of a broad community of scientists. Cell biological processes are controlled by an …

Cellular signaling circuits handle an enormous range of computations. Beyond the
housekeeping, replicating and other functions of individual cells, signaling circuits must …